IBD Crohn’s Colitis Lab Testing You Can Order

Lab Testing

I recommend checking your Inflammatory markers throughout the year at regular intervals so you can track your progress. What gets measured gets managed. What gets managed can improve.

Your lived experience and quality of life is most important. Keeping a regular journal is helpful because we often forget how good things are until they sometimes turn sour. Heck, I can’t even remember what I had for breakfast yesterday!

Crohn's Colitis Lab Testing From Home
The Crohn’s Disease Activity Index (CDAI) and Mayo Score for Ulcerative Colitis Activity are useful tools to consider using.  They access disease activity in Crohn’s and Ulcerative Colitis. For children consider the Pediatric Crohn’s Disease Activity Index(PCDAI ) or Pediatric Ulcerative Colitis Activity Index (PUCAI).

It’s helpful to pair the lived experience with clinical lab testing as sometimes what’s going on deep inside our bodies are not easily felt, and sometimes they are felt too late and a flare-up is imminent. I’d love for you to stay in long term remission and never experience a flare-up again!.

For clinical results, at the very least, I recommend calprotectin checked every 3 or 4 months.

Order Your Lab Tests From Home

Inflammatory markers to track include Calprotectin, a stool test that measures inflammation in the gastrointestinal (GI) tract, C-Reactive Protein which is a blood test marker to test inflammation in the body, and Sed rate, also known as erythrocyte sedimentation rate ( ESR) which is also a blood test used to test inflammation in the body and help monitor the status of inflammation, progression or decline.

Your Doctor can order these test for you or you can order directly from the One Great Gut account at Ultra Lab Tests. This is the first company that not just lets patients order their own labs (and receive the results), but also allows you to submit your receipts to your insurance for billing! Please be sure to check with your insurance, as each company has different rules.

Here are the direct links to the tests at Ultra Lab Tests for your convenience:

– Sed Rate by Modified Westergren (ESR)
Useful in differentiating inflammatory and neoplastic diseases and as an index of disease severity. CRP is also useful in monitoring inflammatory disease states.

– Calprotectin, Stool 
– Calprotectin, Stool – Canada
Indicator of inflammation specifically  in the GI track. Clinical Significance Used to diagnose inflammatory bowel disease (IBD), including Crohn’s disease and ulcerative colitis, or to differentiate IBD from irritable bowel syndrome (IBS).

– C-Reactive Protein Cardiac (hs-CRP)
Also useful in predicting risk for cardiovascular disease

Lactoferrin, Quantitative, Stool
This is an Enzyme-Linked Immunosorbent Assay (ELISA) for measuring concentrations of fecal lactoferrin, a marker for leukocytes. An elevated level is an indicator of intestinal inflammation. The test can be used as an in vitro diagnostic aid to distinguish patients with active inflammatory bowel disease (IBD) from those with noninflammatory irritable bowel syndrome (IBS).

Lactoferrin, Qualitative, Stool
The Lactoferrin IBD-CHEK® is a qualitative (QL) Enzyme Linked Immunosorbent Assay (ELISA) for measuring concentrations of fecal lactoferrin, a marker for leukocytes. A positive level is an indicator of intestinal inflammation. The test can be used as an in vitro diagnostic aid to distinguish patients with active inflammatory bowel disease (IBD) from those with non inflammatory irritable bowel syndrome (IBS).

Fecal Globin by Immunochemistry (InSure®)
The fecal occult blood test is an immunochromatographic fecal occult blood test that qualitatively detects human hemoglobin from blood in fecal samples. This is a useful screening aid for detecting primarily lower gastrointestinal (G.I.) disorders that may be related to iron deficiency anemia, diverticulitis, ulcerative colitis, polyps, adenomas, colorectal cancers or other G.I. lesions that can bleed. It is recommended for use by health professionals as part of routine physical examinations and in screening for colorectal cancer or other sources of lower G.I. bleeding.

Fecal Globin by Immunochemistry (InSure®), Medicare Screen
The fecal occult blood test is an immunochromatographic fecal occult blood test that qualitatively detects human hemoglobin from blood in fecal samples. This is a useful screening aid for detecting primarily lower gastrointestinal (G.I.) disorders that may be related to iron deficiency anemia, diverticulitis, ulcerative colitis, polyps, adenomas, colorectal cancers or other G.I. lesions that can bleed. It is recommended for use by health professionals as part of routine physical examinations and in screening for colorectal cancer or other sources of lower G.I. bleeding.

Another good company to use is True Health Labs who offer more specialized testing. TrueHealthLabs, founded in 2009, was created by a Doctor to make lab testing directly available to those who are uninsured, underinsured, whose doctor refuses to order tests and those who simply want to make their own healthcare choices. Your results will be sent to you via encrypted email. Turnaround times are usually 3-4 business days, however, more complex tests can take 14+ business days.  TrueHealthLabs  saves you 20-80% off lab tests by negotiating directly with CLIA certified labs. With a very high trust rating from thousands of users I am a fan.

They conveniently accept HSA +FSA Accounts, too! 

Some of these tests are more expensive than your usual test, and that is because they give specific insight into certain lab markers that other labs are not able to see. For example, the last time I tested my

pro-inflammatory IL2-TH1 with lab corp they were only able to tell me that I was under 31.2. Not exactly helpful!! CytoDx, seen below, will show you IL2-TH1 with greater granularity, and since we would like it to be below 12, this further shows that the <31 from the other lab is not very useful information.

Antibodies to Saccharomyces cerevisiae
These are found in approximately 75% of patients with Crohn’s disease, 15% of patients with ulcerative colitis, and 5% of the healthy population. High antibody titers increase the likelihood of disease, especially Crohn’s disease, and are associated with more aggressive disease. As the inflammation in Crohn’s disease is focused at the gut mucosa, most patients have IgA antibodies to S cerevisiae and half of these also have IgG antibodies. A minority of patients have only IgG antibodies to S cerevisiae.

TH1 TH2 Cytokine Test – Basic
For those with a confirmed autoimmune condition, the Th1 Th2 test is possibly the most important test. The test points out imbalances in the immune system by looking at cytokines, proteins that the immune system relies on to communicate. Bad communication results in complications for those with autoimmune conditions. The information this test provides helps your doctor develop a strong and effective treatment plan for you, especially when seeking alternative medicine support.
The immune system works like a seesaw. On one side you have Th1 cytokines that initiate the first line of defense. On the other side, you have Th2 cytokines which help produce antibodies to protect you from future invasions. However, when one side goes up, the other side goes down. This can contribute to a weak immune system and potentially promote autoimmune issues. Running this test will help to understand where the imbalance is. Because certain botanicals used in natural medicine can boost Th1 cytokines and Th2 cytokines, this test can help you and your doctor develop an effective plan to help balance a weak immune system and turn the volume down on autoimmune attacks.

TH1 TH2 TH17 Cytokine Test – Advanced aka CytoDX
This test is more detailed than the above with readings including

  • Inflammatory Cytokines- Th1
    • INF Gamma: Th1
    • IL-1 beta: Th1
    • IL-2: Th1
    • IL-6: Th1 and Th2
    • IL-7: Weak Th1
    • IL-8: Weak Th1
    • IL-12 p70: Th1
    • IL-17A: Th17
    • IL-18: Weak Th1
    • TNF alpha- Th1
  • Anti-Inflammatory Cytokines- Th2
    • IL-4: Th2
    • IL-5: Th2
    • IL-10: T-regulatory cells
    • IL-13: Th2
    • IL-15: Weak Th2

TH17 Test
New studies show that an increase in a particular type of white blood cell, called Th17 cells, can trigger and determine the severity of autoimmune conditions. Monitoring Th17 levels can help you and your doctor better treat the condition.

Basic CD4 CD8 Ratio Test
The CD4 CD8 ratio profile helps assess the immune system in detail. This test is crucial for patients who are suspected of having a compromised immune system as seen in autoimmune conditions and HIV.

I recommend to to run the Th1 Th2 test along with this CD4/CD8 ratio test if you have any concerns with an autoimmune condition like Crohn’s or Colitis.

I hope this has been helpful for your health journey!

Categories: CalProctetin, Crohn's Disease, DIAGNOSIS, DIAGNOSTIC TESTING, Hematochezia(Blood in Stool), Inflammation, Stool Analysis, and Ulcerative Colitis.