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Case Study: Camel Milk allows full stop of Entocort steroid and not needing Humira

A case study published in the American Journal of Gastroenterology showed that a 22-year-old patient with moderate to severe Crohn’s Disease showed significant improvement from this milk.

For this article, I’ll call this man John.

His Crohn’s Disease Activity Index(CDAI) score of 400.

According to the Merck Manual, his CDAI reveals mild to moderately active Crohns’ Disease

0 to 149 points:  Asymptomatic remission
150 to 220 points: Mildly to moderately active Crohn’s disease
221 to 450 points: Moderately to severely active Crohn’s disease
451 to 1100 points: Severely active to fulminant disease

John had watery diarrhea and left-sided abdominal pain. His stool cultures were negative, blood was seen in his stool and he was given both Flagyl® and Cipro® in the ER.

A CT scan of the abdomen/pelvis revealed diffused long segment thickening of the terminal ileum and mild thickening of the cecum.

A colonoscopy revealed moderate to severe pancolitis, ulcerations, and cobblestoning of the terminal ileum. Biopsies revealed chronic active colitis, crypt abscesses, and chronic active ileitis.

John started the steroid Entocort(budesonide) at 9mg daily and he saw improvement. According to drugs.com Entocort EC oral delayed-release capsules 3mg  cost $2412.28 for quantity 100. 

Humira (adalimumab)‎ was suggested however John and his family chose an alternative therapy. According to drugs.com a Humira subcutaneous kit costs $5810.97 for  a 2ea kit. AbbVie, the manufacture of Humira states that you may receive vaccines, except for live vaccines while using HUMIRA and that children should be brought up to date with all vaccines before starting HUMIRA

Humira is a a tumor necrosis factor (TNF) blocker indicated for treatment of Rheumatoid Arthritis (RA), Juvenile Idiopathic Arthritis (JIA), Psoriatic Arthritis (PsA), Ankylosing Spondylitis (AS), Adult Crohn’s Disease (CD), Pediatric Crohn’s Disease, Ulcerative Colitis (UC), Plaque Psoriasis (Ps), Hidradenitis Suppurativa (HS) and Uveitis (UV).

AbbVie’s recommend dosage ranges from weekly or every other week.  Based on the drugs.com pricing this would come out to $302,170 or $151,085 annually. Some may qualify for pharmacy card savings.

Instead of Humira, t
hey decided on a natural and more affordable option, namely  Camel Milk, just 8oz three times daily. If you’re in Europe,  use this link.

John’s symptoms reduced enough that he was able to stop Entocort just a week later. Except for right hip pain from Arthritis, his symptoms were completely lessened, according to the case report.

John had another colonoscopy a year later which showed much improvement, with less and shallower ulcerations in his terminal ileum.

Inflammation was now limited to just the cecum and pseudopolyp (scar tissue mass), in just the ascending colon.

He was entirely asymptomatic and even gained 11pounds, increasing from 139 to 150lb.

A multi-site study out of Egypt and Saudi Arabia showed that  Camel Milk (Europe: use this link.)  reduced colitis inflammation and oxidative stress in rats. Both the TNF-a and IL-10 cytokines were checked

To learn which inflammatory markers are high in your body, you can order lab tests from home here

Camel Milk has been known to promote glutathione production, deliver beneficial strains of Oligosaccharides, which contribute to digestive health by decreasing gut permeability and nourishing a healthy microbiome. They also serve as prebiotics. Because oligosaccharides also aid in cell recognition and cell binding, they play a vital role in immune function.

Camel Milk has three times more vitamin C than cow’s milk and 10 times higher in iron. With malabsorption and anemia often problems amongst those with gut dysbiosis, leaky gut, and often those with Crohn’s Disease and Ulcerative Colitis, this could be another reason why Camel Milk yielded such positive results to John.

Several studies on allergies (children who were allergic to dairy and just about everything else) showed significant improvement with camel’s milk They tolerated the milk, healed, and became less allergic and reactive in general.

Goat milk is often more tolerable than Cows milk for adults and children with Crohn’s and Colitis.  Studies have actually shown that Camel Milk is an even safer choice than Goat Milk.

Camel Milk has even been shown to inhibit mycotoxins, including Aspergillus. Mold and mycotoxins are often a  hidden root-cause of Inflammatory Bowel Disease and other auto-immune experiences.

My favorite Camel Milk (Europe: use this link.) company has been featured in the Los Angeles Times, Wall Street Journal, New York Times, and even Time Magazine.

Right now they are offering a risk-free trial. This means that you can return it if you do not like it.

 

Camel Milk also delivers Rare Proteins The most powerful immune active components are Lactoferrin, Immunoglobulins, Cytokines, and Lysozyme. These proteins are unique to camel milk and provide ultimate support to your brain, gut, and immune health. All these are antioxidants that can scavenge free radicals and reduce oxidative stress.


They have been verified by the non-GMO project, are Keto certified, EWG Verified, Gluten-Free, and Paleo Approved.
No Added Hormones, ✓Seasonally Grass-Fed, ✓Non-Homogenized

Camel milk (Europe: use this link.) contains a low-fat content of 2% and these fats are mostly omegas. The proteins are thought to contain a number of powerful bactericides, viricides, and fungicides. The immune proteins are 1/10 the size of human ones and are very potent. Some of the proteins are thought to repair tissue damage. The potential efficacy of camel milk in Crohn’s disease has not been studied although there are antidotal accounts for its effectiveness. It is, therefore concluded that camel milk has the potential of repairing damaged tissue. Further studies need to be done.

References

The inhibitory effect of camel’s urine on mycotoxins and fungal growth: African Journal of Agricultural Research: Amira Hassan Abdullah Al-Abdalall: Department of Botany and Microbiology, Faculty of Science for Girls, King Faisal University, El-Dammam, Kingdom of Saudi Arabia: 2010:
https://academicjournals.org/journal/AJAR/article-abstract/43879C334505

 

International Scholarly Research Notices: Camel Milk Is a Safer Choice than Goat Milk for Feeding Children with Cow Milk Allergy: Mohammad Ehlayel,  Abdulbari Bener, Khalid Abu Hazeima,  and Fatima Al-Mesaifri 

International Journal for Vitamin and Nutrition Research – Z. Farah, R.Rettenmaier, D. Atkins:  Vitamin Content of Camel Milk: 1991: 1 Laboratory of Dairy Science, Swiss Federal Institute of Technology Switzerland and Ol Maisor Farm Rumuruti Kenya:

International Journal of Research Studies in Biosciences (IJRSB): Camel Milk: A Boon to Mankind
Wajiha Gul, Najaf Farooq, Dania Anees, Uroosa Khan, Filza Rehan.
Faculty of Pharmacy, Jinnah University for Women, Karachi, Pakistan
https://www.arcjournals.org/pdfs/ijrsb/v3-i11/4.pdf

https://www.merckmanuals.com/medical-calculators/CDAI.htm

Predicting the Crohn’s disease activity index from the Harvey-Bradshaw Index
https://pubmed.ncbi.nlm.nih.gov/16633052/

Development of a Crohn’s disease activity index. National Cooperative Crohn’s Disease Study
https://pubmed.ncbi.nlm.nih.gov/1248701/

Camel Milk as an Alternative Treatment for Crohn’s Disease
Rosenheck, David MD; Ravee, Yaniv MS; Yagil, Reuven DVM
https://journals.lww.com/ajg/Fulltext/2012/10001/Camel_Milk_as_an_Alternative_Treatment_for_Crohn_s.1264.aspx

JFK Medical Center in Edison, NJ,  University of Medicine of New Jersey in Newark, NJ and Ben-Gurion University of The Negev, Beer Sheva, Israel.

Food and Chemical Toxicology: Camel’s milk ameliorates TNBS-induced colitis in rats via downregulation of inflammatory cytokines and oxidative stress
Hany H Arab, Samir Salamaa,  Ahmed H Eidde, Hany A Omard, El-Shaimaa A Arafad, Ibrahim A Maghrabi
Taif University, Saudi Arabia, Cairo University, Cairo Egypt, National Organization for Drug Control and Research (NODCAR), Dokki, Cairo, Egypt, Beni-Suef University, Beni-Suef
https://www.sciencedirect.com/science/article/abs/pii/S0278691514002142?via%3Dihub

Abbvie Humira Medicine Guide  https://www.rxabbvie.com/pdf/humira_medguide.pdf and https://www.rxabbvie.com/pdf/humira.pdf
Drugs.com: Humira: One Drug, Nine Uses, Billions of Dollars: https://www.drugs.com/slideshow/humira-one-drug-nine-uses-billions-of-dollars-1210

 

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Accidental Fear or Valid reporting? Risk of New IBD Rises for Patients Treated With Etanercept

The Center for Biosimilars today published an article that concluded that there is a fearful risk of being diagnosed with IBD Crohn’s or Colitis for those currently being treated with Etanercept.

Respectfully, I believe this study is incomplete and does not tell the full story. Though I don’t currently have access to the full study, just the Wiley Online Library Summary and the Center for Biosimilars article, until Lifestyle and Diet are factored into these studies I believe they do not tell the complete story.  20 years of clinical and cost outcomes from Integrative Medicine* have demonstrated the following results:

60% Decrease in hospital admissions
59% Reduction in hospital days
62% Savings in Outpatient surgeries and procedures
85% Reduction in Pharmaceutical costs
*Data provided by Patient-centered integrative medicine Independent Practice Association (IPA) per Advanced Medicine Integration Group, L.P. (AMI)

With the efficacy of leverage of using Integrative Medicine Lifestyle and Dietary changes, and the rise of it’s usage I believe a study like this is incomplete and may be unintentionally promoting accidental fear. What do you think?

Combined with the recent news that the United States Congress is grappling with tainted Chinese drugs, baffled by lack of FDA oversight in the U.S. pharmaceutical supply chain*. Remember when lead paint in children’s toys were a problem? That’s nothing compared to my concern to FDA Approved drugs potentially containing unwanted excipients.

As shown by the patients I interviewed during the Crohn’s And Colitis Summit who believe they are now cured of IBD Crohn’s and Colitis it’s becoming increasingly apparent for all of us to pay attention to our Physical, Mental, Emotional and Spiritual healing and growth.

Etanercept is a biopharmaceutical that treats autoimmune diseases by interfering with tumor necrosis factor by acting as a TNF inhibitor. It has U.S. F.D.A. approval to treat rheumatoid arthritis, juvenile idiopathic arthritis and psoriatic arthritis, plaque psoriasis and ankylosing spondylitis.

They state that while anti-tumor necrosis factor (anti-TNF) drugs are effective at treating a range of inflammatory diseases, some limited data suggest that they may, paradoxically, result in a higher risk of developing other de novo inflammatory conditions.

It’s worth mentioning that anti-TNF drugs are not the only drugs available to those with inflammatory diseases. Recently the United States FDA approved Stelara for ulcerative colitis. It’s also important to note that there are different inflammatory markers in the body. TNFa is only one of those markers. When my TNFa was low, I failed Remicade. Though this was the recommendation of my then specialist Doctors, it seemed apparent to me that I would fail Remicade, and subsequently, I did. This resulted in a horrific QOL(Quality of Life) and a very small regretful view of the world and shitty symptoms.  In hindsight, I should never have tried Remicade knowing that my TNFa was within the normal range. If you are wondering what your inflammatory markers look like I recommend ordering a test from this page: IBD Crohn’s Colitis test you can order from home.

Recently, Danish researchers sought to assess whether there is a link between anti-TNF therapy and the development of inflammatory bowel disease (IBD).1 Using nationwide Danish registries, the group examined data for all patients with rheumatoid arthritis, psoriasis, psoriatic arthritis, ankylosing spondylitis, pemphigus, alopecia areata, and vitiligo who were enrolled between 1994 and 2017. Anti-TNF agents were introduced in Denmark in 2004, and there were 17,018 individuals who had been exposed to anti-TNF drugs and 63,308 who had not been exposed.

Overall, 7344 patients were treated with infliximab, 9072 were treated with etanercept, and 8355 were treated with adalimumab. Fewer patients were treated with golimumab (n = 1973) or certolizumab pegol (n = 2503). Overall, 34.1% of patients were exposed to 2 anti-TNF drugs, and 16.7% were exposed to 3 or more.

The researchers found that patients treated with etanercept had a significant increase in the risk of developing new Crohn disease (CD), with an adjusted hazard ratio (HR) of 2.0 (95% CI, 0.8-2.2). The adjusted HRs for developing CD were 1.3 (95% CI, 0.8-2.22) for infliximab and 1.2 (95% CI, 0.8-1.8) for adalimumab. There was no statistically significant increased risk for new CD with golimumab or certolizumab pegol.

Additionally, patients treated with etanercept had a significant increase in the risk for developing new ulcerative colitis (UC), with an adjusted HR of 2.0 (95% CI, 1.5-2.8). The adjusted HRs for developing new UC were 1.0 (95% CI, 0.6-1.6) for infliximab and 0.6 (95% CI, 0.3-1.0) for adalimumab. Again, there was no statistically significant increased risk for new UC with golimumab or certolizumab pegol.

According to the authors, “This study firmly establishes the risk of developing de novo IBD while on anti‐TNFα agents, particularly with etanercept.”

In a letter linked to the publication, a separate group of authors from the centers in China noted that a different TNF binding pattern may be responsible for the increased risk of new IBD with etanercept versus other anti-TNFs.2

Etanercept binds to 2 of 3 sites of the TNF molecule, while infliximab binds to all 3, they explain. Additionally, unlike infliximab or adalimumab, etanercept does not bind to peripheral blood cells and lamina propria mononuclear cells derived from patients with IBD. Infliximab and etanercept also have different effects on cytokine production of T lymphocytes, “possibly inducing IBD in genetically predisposed patients,” say the authors, adding that more research into IBD-triggering pathways is warranted.

Lessons Learned:

If you’re unsure which pro-inflammatory markers are high in your body, consider your options here: IBD Crohn’s Colitis test you can order from home. Doctor approval is direct from the companies listed, you do not need to obtain prior approval from your personal Doctor, which can lead to unwanted delays, or being denied to have the blood test you wish to see the results of for your body to make the most educated decision for your health.

Any purchase from the lab test companies on that page, or the below links will allow the One Great Gut Foundation to get closer to meeting our initiatives which help you Thrive with IBD Crohn’s and Colitis. So you can invest in your health and build a healthier world through our initiatives, at the same time. Thrive Physically, Mentally, Emotionally and Spiritually.

Monitoring your health. The Crohn’s Disease Activity Index (CDAI) and the Simple Clinical Colitis Activity Index (SCCAI) are useful tools to consider using.  They access disease activity in Crohn’s and Ulcerative Colitis. For children, consider the Pediatric Crohn’s Disease Activity Index(PCDAI ) or Pediatric Ulcerative Colitis Activity Index (PUCAI).

Lab Tests to Consider

TH1 TH2 Cytokine Test – Basic
For those with a confirmed autoimmune condition, the Th1 Th2 test is possibly the most important test. The test points out imbalances in the immune system by looking at cytokines, proteins that the immune system relies on to communicate. Bad communication results in complications for those with autoimmune conditions. The information this test provides helps your doctor develop a strong and effective treatment plan for you, especially when seeking alternative medicine support.

The immune system works like a seesaw. On one side you have Th1 cytokines that initiate the first line of defense. On the other side, you have Th2 cytokines that help produce antibodies to protect you from future invasions. However, when one side goes up, the other side goes down. This can contribute to a weak immune system and potentially promote autoimmune issues. Running this test will help to understand where the imbalance is. Because certain botanicals used in natural medicine can boost Th1 cytokines and Th2 cytokines, this test can help you and your doctor develop an effective plan to help balance a weak immune system and turn the volume down on autoimmune attacks.

TH1 TH2 TH17 Cytokine Test – Advanced aka CytoDX
This test is more detailed than the above with readings including

  • Inflammatory Cytokines- Th1
    • INF Gamma: Th1
    • IL-1 beta: Th1
    • IL-2: Th1
    • IL-6: Th1 and Th2
    • IL-7: Weak Th1
    • IL-8: Weak Th1
    • IL-12 p70: Th1
    • IL-17A: Th17
    • IL-18: Weak Th1
    • TNF alpha- Th1
  • Anti-Inflammatory Cytokines- Th2
    • IL-4: Th2
    • IL-5: Th2
    • IL-10: T-regulatory cells
    • IL-13: Th2
    • IL-15: Weak Th2

TH17 Test
New studies show that an increase in a particular type of white blood cell, called Th17 cells, can trigger and determine the severity of autoimmune conditions. Monitoring Th17 levels can help you and your doctor better treat the condition.

Basic CD4 CD8 Ratio Test
The CD4 CD8 ratio profile helps assess the immune system in detail. This test is crucial for patients who are suspected of having a compromised immune system as seen in autoimmune conditions and HIV.

Any purchase from the lab test companies above using the above links will allow the One Great Gut Foundation to get closer to meeting our initiatives which help you Thrive with IBD Crohn’s and Colitis. So you can invest in your health and build a healthier world through our initiatives, at the same time. Thrive Physically, Mentally, Emotionally and Spiritually.

References
1. Korzenik J, Larsen MD, Nielsen J, Kjeldsen J, Norgard BM. Increased risk of developing Crohn’s disease or ulcerative colitis in 17,018 patients while under treatment with anti‐TNFα agents, particularly etanercept, for autoimmune diseases other than inflammatory bowel disease. Aliment Pharmacol Ther. 2019;50(3):289-294. doi: 10.1111/apt.15370.

2. Dai C, Jian M, Sun MJ. Letter: increased risk of developing Crohn’s disease or ulcerative colitis in 17 018 patients while under treatment with anti‐TNFα agents, particularly etanercept, for autoimmune diseases other than IBD. Aliment Pharmacol Ther. 2019;50(7):834-835. doi: 10.1111/apt.15460.

3. AP&T – Alimentary Pharmacology and Therapeutics – Increased risk of developing Crohn’s disease or ulcerative colitis in 17 018 patients while under treatment with anti‐TNFα agents, particularly etanercept, for autoimmune diseases other than inflammatory bowel disease – Joshua Korzenik Michael Due Larsen Jan Nielsen Jens Kjeldsen Bente Mertz Nørgård First published: 02 July 2019 https://doi.org/10.1111/apt.15370  The Handling Editor for the article was Professor Richard Gearry, and it was accepted for publication after full peer‐review. Funding information: University of Odense Hospital Free Research Foundation.

* Newsweek October 2019 Congress grappling with tainted Chinese Drugs, is baffled by lack of FDA oversight in U.S. Pharmaceutical supply chain by Blake Dodge
https://www.newsweek.com/congress-spooked-tainted-chinese-drugs-eyeing-pharmaceutical-supply-chain-1468753?fbclid

* Newsweek December 2019 U.S. DRUG PRICES TO RISE IN 2020 AS COMPANIES PREPARE TO CHARGE MORE FOR IBRANCE, XELJANZ, 200 OTHERS by Jeffrey Martin
https://www.newsweek.com/us-drug-prices-rise-2020-companies-prepare-charge-more-ibrance-xeljanz-200-others-1479939

Categories
Case Study DIAGNOSIS EAT Herbal Medicine Nutrition Pharmaceuticals Recipies Resources STORIES-OF-HOPE The Crohn's And Colitis Summit

The Crohns Colitis Summit Changed My Life. Don’t give up the good fight! You are bringing so much healing to the world….

…that’s what Mia emailed me. After asking her to elaborate, this is what she said next:

I have rheumatoid arthritis. I got diagnosed at the end of 2016, with a 4 months wait to see a rheumatologist, on state insurance because I wasn’t able to work from the pain and fatigue, and with Trump attacking the ACA I was terrorized over the idea of being dependent on the US medical system and then being denied coverage.
I decided to seek further education in proactive healthcare I could rely on. I spent that time doing AIP to see if anything besides gluten was triggering my flares and researching anything holistic or lifestyle-related that I could try to help my symptoms. I was terrified of pharma, and putting off trying it. My rheumatologist was hitting the scare tactics pretty hard, so I didn’t really trust him. But they were ok monitoring my attempts with the diet etc. And just checking in every 4 months. They had nothing to offer me except to take the meds and no real dialogue about the medications.

Note: For credible AIP information check out The Alternative Autoimmune Cookbook: Eating for All Phases of the Paleo Autoimmune Protocol by Angie Alt and the SAD to AIP in SIX online course which runs a few times a year.

I signed up dor anything autoimmune-related because I realized that was the better diagnosis. Sticking to RA focused information isolated me from a larger pool of information. So I signed up for the Crohns And Colitis Summit. And I saw you had an interview with Dr. Konijeti about medication. I trusted her input because she led that study on the AIP diet. Your interview questions were SO good and her answers were equally valuable. After that interview, all my questions about medication were touched on, and I felt better about trying pharma. I also noticed in the interviews with people who are controlling their AI without medication, there was a common pattern. They used pharma to break the inflammation cycles and get to a place where they could maintain their status quo without the medication.
I’m now 14 months pain-free. 20 months on medication. We’re planning to start trying to conceive my first child next month. Which was my dearest dream for getting my RA under control.
I’ve learned so much. A big one no one talks about is how autoimmune diseases are often catabolic that means recovery and ramping down the immune system includes expected weight gain as the metabolism adjusts. For a woman, that is terrifying in our society. Its a huge fear for us in everyday situations, and will stop a woman from continuing treatment.
Its been a wild 2 years. Your summit was a big turning point in my approach to treatment. By the time I started meds, I was a peace with it, and I think that absolutely contributed to how fast my first medication worked for me.
So. Thank you.
Mia Maria Siler
Categories
Biologics C-reactive protein (CRP) CalProctetin Colonoscopy Crohn's Disease Nutrition One Great Gut Collection Pharmaceuticals RESEARCH Resources STORIES-OF-HOPE The Crohn's And Colitis Summit TREATMENT Ulcerative Colitis

US FDA approves Stelara for ulcerative colitis

Do you find these articles helpful? Please donate today so we may continue this service so humanity may prosper in a peaceful world with a peaceful microbiome

This past October, the U.S. Food and Drug Administration approved ustekinumab (Stelara by Janssen), a human IL-12 and IL-23 antagonist.

This is based on data from a phase 3 UNIFI trial, which demonstrated that ustekinumab induced and maintained clinical remission in a significantly greater proportion of adults with moderately to severely active UC compared with placebo.

Trial And Study Results

Janssen said at the time the UNIFI data was released that at Week 8, the trial data showed Stelara hit some of its major secondary endpoints, which includes the proportion of patients in clinical response, endoscopic healing, as well as health-related quality of life scores. In addition, Janssen said that at least 50 percent of study participants were considered biologically refractory, and 17 percent had a history of inadequate response or intolerance to any anti-TNF antibody and Takeda’s Entyvio (vedolizumab). It is unknown if diet and lifestyle were tracked in these studies.

Stelara, Janssen said, is the first and only approved biologic therapy for UC that targets the interleukin (IL)-12 and IL-23 cytokines. The IL-12 and IL-23 cytokines have been shown to play an important role in inflammatory and immune responses.

The UNIFI trial includes an initial induction study and was followed by a maintenance study eight weeks later where patients received subcutaneous injections of Stelara every 8 weeks for 44 weeks. In the Induction study, 19% of patients receiving Stelara achieved clinical remission in 8 weeks. Janssen also noted that Stelara provided rapid relief of symptoms as 58 percent of patients experienced a clinical response at Week 8. It is not known what diet or lifestyle factors were being implemented by the patients during the study

In the maintenance study, 45% of patients who received Stelara remained in remission after one year. Stelara also helped patients achieve clinical remission without the use of corticosteroids, the company noted. At the end of the first year, 43% of patients treated with Stelara were in clinical remission and not receiving steroids, Janssen said. At the risk of sounding repetitive, it is not known what diet or lifestyle factors were being implemented by the patients during the study. Not the downplay the efficacy and results of these studies and trials, we know from both the Crohn’s And Colitis Summit and One Great Gut Collection that Diet and Lifestyle alone can induce long term remission, deep mucosal healing sometimes confirmed by visual examination via Colononsocopy per the patient request, sometimes simply confirmed by a high Quality of Life, Thriving lifestyle, and lack of debilitating symptoms

In addition to the latest approval from the FDA, Stelara has been approved as a treatment for adults living with moderate to severe plaque psoriasis, adolescent patients with moderate to severe plaque psoriasis, adults with active psoriatic arthritis and adults with moderately to severely active Crohn’s disease. The drug brings in about $4 billion in annual sales which shows the need for this drug in today’s current environment and the additional need for Dietary and Lifestyle guidance.

If you’re unsure which pro inflamantroy markers are high in your body, consider your options here: IBD Crohn’s Colitis test you can order from home. Doctor approval is direct from the companies listed, you do not need to obtain prior approval from your personal Doctor, which can lead to unwanted delays, or being denied to have the blood test you wish to see the results of for your body to make the most educated decision for your health.

Monitoring your health. The Crohn’s Disease Activity Index (CDAI) and  Simple Clinical Colitis Activity Index (SCCAI) are useful tools to consider using.  They access disease activity in Crohn’s and Ulcerative Colitis. For children, consider the Pediatric Crohn’s Disease Activity Index(PCDAI ) or Pediatric Ulcerative Colitis Activity Index (PUCAI).

Lab Tests to Consider

TH1 TH2 Cytokine Test – Basic
For those with a confirmed autoimmune condition, the Th1 Th2 test is possibly the most important test. The test points out imbalances in the immune system by looking at cytokines, proteins that the immune system relies on to communicate. Bad communication results in complications for those with autoimmune conditions. The information this test provides helps your doctor develop a strong and effective treatment plan for you, especially when seeking alternative medicine support.

The immune system works like a seesaw. On one side you have Th1 cytokines that initiate the first line of defense. On the other side, you have Th2 cytokines that help produce antibodies to protect you from future invasions. However, when one side goes up, the other side goes down. This can contribute to a weak immune system and potentially promote autoimmune issues. Running this test will help to understand where the imbalance is. Because certain botanicals used in natural medicine can boost Th1 cytokines and Th2 cytokines, this test can help you and your doctor develop an effective plan to help balance a weak immune system and turn the volume down on autoimmune attacks.

TH1 TH2 TH17 Cytokine Test – Advanced aka CytoDX
This test is more detailed than the above with readings including

  • Inflammatory Cytokines- Th1
    • INF Gamma: Th1
    • IL-1 beta: Th1
    • IL-2: Th1
    • IL-6: Th1 and Th2
    • IL-7: Weak Th1
    • IL-8: Weak Th1
    • IL-12 p70: Th1
    • IL-17A: Th17
    • IL-18: Weak Th1
    • TNF alpha- Th1
  • Anti-Inflammatory Cytokines- Th2
    • IL-4: Th2
    • IL-5: Th2
    • IL-10: T-regulatory cells
    • IL-13: Th2
    • IL-15: Weak Th2

TH17 Test
New studies show that an increase in a particular type of white blood cell, called Th17 cells, can trigger and determine the severity of autoimmune conditions. Monitoring Th17 levels can help you and your doctor better treat the condition.

Basic CD4 CD8 Ratio Test
The CD4 CD8 ratio profile helps assess the immune system in detail. This test is crucial for patients who are suspected of having a compromised immune system as seen in autoimmune conditions and HIV.

Any purchase from the lab test companies above using the above links will allow the One Great Gut Foundation to get closer to curing IBD Crohn’s and Colitis. So you can invest in your health and build a healthier world through our initiatives, at the same time.

Stelara Efficacy and Frequency

Many of us are already familiar with the efficacy and safety of ustekinumab in Crohn’s disease given that it has been commercially available for more than 3 years now,” Edward V. Loftus Jr., MD, Chief Medical Editor of Healio Gastroenterology and Liver Disease, said in an interview. The approval was based on the UNIFI induction and maintenance trials, which was published late last month in The New England Journal of Medicine. Along with the usual endpoints, ustekinumab was found to be significantly more effective than a placebo at inducing and maintaining a combined endpoint of both endoscopic and histologic improvement.”

The first dose of ustekinumab will be administered intravenously in a health care facility. After that, the remaining doses will be given subcutaneously 8 weeks after the first dose and then every 8 weeks thereafter. Sometimes varying frequencies outside of the 8-week window is needed. I know of patients who are approved to take ustekinumab every 6 or 7 weeks to manage their symptoms.

Lifestyle and Diet

In many patients, diet and lifestyle changes have increased the success of ustekinumab and decreased unwanted side effects. To learn about the most effective dietary and lifestyle techniques that worked for other’s who found full remission, some claiming they are cured, with evidence-backed by Colonoscopy which showed no sign of IBD, ever. As a matter of fact the Gastroentrolgist stated that if the patient had not let him know that they previously had a challenging case of Crohn’s or Colitis, they would never have known. ref: Crohn’s And Colitis Summit and One Great Gut Collection

Remember, what works for one may not work for another. I recommend that you allow Science to be your map, and intuition to be your compass. We’ve noticed that healing is accelerated when the patient heals themselves not just Physically, but also Emotionally, Mentally and Spiritually.  As a matter of fact I’ve interviewed some who claim to be cured, simply by doing the work mentally(Paul), or spiritually(Joshua).

Look, You didn’t get into this alone, and you aren’t getting out of it that way, either. Join this community and your poops will soon shine. Friends don’t let friends suffer alone.

I’ve been Thriving with IBD since 2019

Are you looking for more information on how you too can Thrive with IBD? Join our email list(No Spam, No nonsense, no longer daily, just useful updates) and follow us on Instagram(@onegreatgut) Twitter and Facebook. I’m also on TikTok and Snapchat but don’t post there often and have no idea what I’m doing there except enjoying the creativity of the next generation. Does anyone want to help me out there?

Do you find these articles hgelpful?  Please donate today so we may continue this service so humanity may prosper in a peaceful world with a peaceful microbiome

Note: Originally published in December 2019, this article has been revised and updated for accuracy and thoroughness.

Ref:
Healio Gastroenterology and Liver Disease
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Biologics Crohn's Disease DIAGNOSTIC TESTING Pharmaceuticals RESEARCH TREATMENT

Researchers discover critical link to controlling inflammation in Crohn’s disease

To aggregate the most appropriate IBD news we are republishing this article. This was first reported by Case Western Reserve University in MedicalXpress. We updated the article for further accuracy.
(Thank You Dr. Peter Spiegel for bringing this breakthrough to our attention)

Investigators at the Case Western Reserve University School of Medicine discovered that blocking interleukin-1α (IL1α), a protein that controls inflammation in the gut, markedly decreases the severity of intestinal inflammation in a mouse model of Crohn’s disease (CD).

The anti-inflammatory effects of the biological therapies used to neutralize IL1α were similar to those of steroids, which represent what is generally considered the gold standard of treatment for these patients. In addition, the researchers found that the effect of anti-IL1α treatment was controlled by changing the composition and function of the gut microbiome.

Their findings will be published online the week of Dec. 16 in the Proceedings of the National Academy of Sciences.

“This is one of the first studies, to our knowledge, that links the effect of a specific cytokine, such as IL1, to the gut microbiome,” said lead author Fabio Cominelli, professor of medicine and pathology at Case Western Reserve University, and division chief of gastroenterology at University Hospitals Cleveland Medical Center.

Furthermore, the study provides the preclinical rationale for performing the first clinical trial blocking interleukin-1 in patients with inflammatory bowel disease (IBD), which Cominelli and his collaborators at Xbiotech Inc., a biosciences company based in Austin, Texas, who developed a human monoclonal antibody against IL1α, are planning for the near future.

“I’m really excited about this study because I started my career three decades ago collaborating with (co-author) Dr. Charles Dinarello, professor of medicine at the University of Colorado, who discovered and cloned interleukin-1 in the early ’80s,” Cominelli said. “Now I have the opportunity to collaborate again with him in this exciting project that has the potential to develop a novel biological therapy for patients with IBD.”

IBD, which refers to Crohn’s disease and ulcerative colitis, affects more than three million adults in the United States, according to the Centers for Disease Control and Prevention. and 10 Million Worldwide according to the European Federation of Crohn’s & Ulcerative Colitis Associations (EFCCA). This estimate does not include children who may also have IBD, who are being diagnosed younger and with more aggressive cases than ever before.. Most people with IBD are diagnosed in their 20s and 30s, according to the CDC.

These ailments are chronic, relapsing, inflammatory conditions of the gastrointestinal system characterized by severe pain, diarrhea, bleeding and sometimes intestinal complications requiring surgery. Woman with Ulcerative Colitis who require surgery have seen their fertility rates drop by one-third.

To date, there is no cure for these devastating diseases, and available conventional medicine therapies are effective in only about half of IBD patients.

“Therefore, there is a great need for developing new biological therapies, such as anti-IL1 monoclonal antibodies,” Cominelli said.

Some of those interviewed for the Crohn’s And Colitis Summit would disagree as they believe they are cured. Some no longer require a special diet.

BTW – Looking To Order Blood Tests Without The Hassle Of Going Through Your Doctor and Insurance Companies Approval? Now you can, read more here. HSA +FSA Accounts accepted.

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Asacol Corticosteroids Enemas Lialda-Mesalamine Pharmaceuticals Prednisone-Deltasone Rowasa Suppository TREATMENT

Pharmaceutical Options

  • Aminosalicylates (5-ASA) – Oral
    • Sulfasalazine [Azulfidine, Azulfidine EN-tabs]
    • Mesalamine [Lialda, Pentasa, Delzicol, Asacol HD] Olsalazine [Dipentum]
    • Balsalazide [Giazo, Colazal]
  • Aminosalicylates (5-ASA) – Rectal suppositories and enemas
    • Mesalamine [Canasa, Rowasa, sfRowasa]

  • Corticosteroids and Glucocorticoids
    • Prednisolone [Pred Forte, Omnipred, Pred Mild, , Orapred ODT, Millipred DP, Veripred 20, and Pediapred]
    • Prednisone [Deltasone, Rayos, Prednisone Intensol]
    • Budesonide [Entocort, Uceris, Pulmicort, Rhinocort Allergy, and Pulmicort Flexhaler]
    • Methylprednisolone [Solu-Medrol, Medrol, ReadySharp Methylprednisolone, P-Care D40, P-Care D80, and Depo-Medrol]

  • Immunosuppressive and Immunomodulators
    • Ustekinumab [Stelara]
    • Adalimumab [Humira, Humira Pen, Humira Pen Crohn’s-UC-HS Start, Humira Pediatric Crohn’s Start, Humira, and Humira Pen Psoriasis-Uveitis]
    • Azathioprine [Azasan, Imuran]
    • Infliximab [Remicade]
    • Cyclosporine [ Sandimmune, Restasis MultiDose, Neoral, Restasis, and Gengraf]
    • Tacrolimus [Envarsus XR, Astagraf XL, Protopic, and Prograf]
    • Golimumab [Simponi ARIA and Simponi]
    • Etanercept [Enbrel, Benepali]
  • Immunosuppressive And Chemotherapy
    • 6-mercaptopurine, 6-MP [Purinethol, Purixan]
    • Methotrexate[Otrexup (PF), Xatmep, Trexall]

      Pain Relievers

      Orexigenic
    • Dronabinol [Marinol]

      Analgesic
    • Acetaminophen [TYLENOL, Ofirmev, FeverAll, Tylophen, Pharbetol, Infant’s Pain Relief, Mapap, Tactinal Extra Strength, PediaCare Fever Reducer, Non-Aspirin Extra Strength]

      Nonsteroidal Anti-Inflammatory Drugs (NSAIDs)I
    • Ibuprofen [Advil, NeoProfen, Caldolor, Ibuprofen IB, Advil Liqui-Gel, Infant’s Motrin, Infant’s Ibuprofen, Infant’s Advil, Children’s Profen IB, Ibu-Drops]
    • Ketorolac [Toradol, Acuvail, Acular LS, Acular, and ReadySharp ketorolac]

      I recommend trying to stay away from NSAIDs as I’ve personally gone from normal bowel movements to bleeding ulcers just from taking NSAIDs. During one hgospitlziation one medical doctgor hospitalzie conmvicend me, in my vulnerble state, that Toradol has  different MOA(Mechanism Of Action and would not cause any problems. Since I was in a high level of pain, and not thinking clearly,  I agreed. Thankfully the GI and ID team overulled that decision a few days later to save me from further complications. 


      GABA Analogue
    • Gabapentin [Gralise, Neuraptine, Gralise 30-Day Starter Pack, SmartRx Gaba-V Kit, Horizant, and Neurontin]

      Anesthetic
    • Ketamine [Ketalar, Ketanest, and Ketaset]

      Opioids / Narcotics
    • Codeine (only available in generic form)
    • Fentanyl (Actiq, Duragesic, Fentora)
    • Hydrocodone (Hysingla ER, Zohydro ER)
    • Hydrocodone/acetaminophen (Lorcet, Lortab, Norco, Vicodin)
    • Hydromorphone (Dilaudid, Exalgo)
    • Meperidine (Demerol)
    • Methadone (Dolophine, Methadose)
    • Morphine (Astramorph, Avinza, Kadian, MS Contin, Ora-Morph SR)
    • Oxycodone (OxyContin, Oxecta, Roxicodone)
    • Oxycodone and acetaminophen (Percocet, Endocet, Roxicet)
    • Oxycodone and naloxone (Targiniq ER)
  • Janus Kinase (JAK) Inhibitor 
    •  Tofacitinib [Xeljanz, Jakvinus]

  • Biologic/Biosimilar Therapies
    • Adalimumab [Humira Pen, Humira Pen Crohn’s-UC-HS Start, Humira Pediatric Crohn’s Start, Humira, and Humira Pen Psoriasis-Uveitis]
    • Golimumab [Simponi ARIA and Simponi]
    • Infliximab [Remicade]
    • Vedolizumab [Entyvio]
    • Infliximab-abda
    • Infliximab-dyyb
    • Infliximab-qbtx

  • Antibiotics:
    • Metronidazole [Flagyl]
    • Ciprofloxacin [Cipro, Proquin]
    • Rifaximin [Xifaxan]
    • Ampicillin
    • Tetracycline
    • Augmentin [ AugmentinXR, Augmentin ES-600, and Augmentin]

  • Calceineurin inhibitor
    • Tacrolimus [Envarsus XR, Astagraf XL, Protopic, and Prograf]
Categories
Crohn's Disease Digestive Enemas Pharmaceuticals Supplements Suppository Ulcerative Colitis

Therapeutic Retention Enemas: An Underutilized Modality for Ulcerative Colitis

The use of therapeutic enemas has a robust tradition in the history of naturopathic medicine. In addition, my own grandfather, a medical doctor, had a habit of administering a cleansing enema to any of his 8 children who displayed any sign of acute illness, which, in the words of my brother, “if nothing else, probably cut down on malingering.” Despite these facts, I made it into my 30s and through my entire professional training as a naturopathic doctor without having given, received, or even witnessed an enema of any type.

This article focuses on the use of enemas in ulcerative colitis (UC) – an autoimmune inflammatory bowel disease (IBD). Two-thirds of UC patients have distal disease, confined to the left side of the colon. Therapeutic retention enemas are highly indicated for this population, but may also be utilized for patients with more extensive disease, up to and including pancolitis.

Rectally-administered therapies are underutilized in IBD, due in part to physician perception of patient unwillingness to use them, and embarrassment in discussing rectal modalities1; however, in my practice I’ve prescribed and administered hundreds of enemas and found them to be extremely helpful in the treatment of UC, especially left-sided UC and ulcerative proctitis, the latter of which is notoriously stubborn to medical management.

ENEMAS, IN GENERAL

An enema, meaning “to send in,” is also known as a clyster, meaning “to wash out.” These 2 etymologies reflect the 2 basic types of enemas: retention enemas are used to deliver a medicinal substance to the colorectum for topical action or absorption via the mucosa, while cleansing enemas are used to wash out the contents of the colon.

Retention enemas are the topic of this article. They can be delivered in a small volume, for example half-ounce (15 mL) vitamin E or colostrum enemas, 60 mL mesalamine enemas, or 100 mL butyrate enemas, or in even larger volumes, such as 500+ mL calendula tea enemas. Retention enemas are generally considered safe for patients with IBD; however, incorrect insertion method has on rare occasion been associated with rectal perforation.2

Cleansing enemas can be small-volume, eg, 4.5 oz hyperosmostic sodium phosphate or lubricant oil enemas, or large-volume, as in the case of water cleansing enemas ranging from 500 to 1500 mL in volume.

There’s a bit of an art to judging what volume is appropriate for a given patient, and the tolerable volume might change depending on the severity of the patient’s disease state, time of day, most recent meal, and other factors. Patients with UC often experience frequent, loose, and urgent stool, so retaining even small-to-moderate volumes can be challenging. Helping them to find the best time of day and time to administer in relation to eating, as well as managing urgency and frequency with oral interventions – ranging from curcumin and activated charcoal to loperamide, cholestyramine, and prednisone – can assist them in retaining therapeutic enemas for long enough to realize benefit from them.

VITAMIN E

Vitamin E, an antioxidant and anti-inflammatory, acts as a healing nutrient when applied topically. In an open-label trial, 14 patients with mild-to-moderately active distal UC self-administered about half an ounce of d-α-tocopherol (8000 IU) QD for 12 weeks.3 At 4 weeks 21% were in remission, and at 12 weeks 64% were in remission. The erythrocyte sedimentation rate (ESR) dropped 80% during this time. Since this trial was published, I have used vitamin E retention enemas with my patients with distal colonic IBD, either alone or in combination with other rectal therapies. Several patients have experienced discernible improvement over time, which we attribute to the vitamin E enemas.

Summary:
Small-volume, liquid vitamin E retention enemas (8000 IU), when used for 2-12+ weeks, may contribute to remission in patients with distal UC.

COLOSTRUM

Colostrum is an immunoglobulin-rich, post-partum, pre-milk mammary gland secretion that is crucial for the health of newborn mammals. Humans have used bovine colostrum orally for many conditions. In a randomized, double-blinded trial, 14 patients with mild-to-moderately active distal UC self-administered half an ounce of liquid colostrum or a control solution rectally BID for 4 weeks.4 At the end of this time period there was a significant improvement in histological scores in the colostrum group, and at 6 months only 13% of the colostrum group required steroids (vs 50% of the placebo enema group). I have used liquid colostrum enemas in my practice, but not for long enough to comment yet on their efficacy.

Summary:
Small-volume, liquid colostrum retention enemas (half-ounce), when used daily for 4 weeks, appear to significantly improve colon mucosal healing and decrease steroid dependence in patients with distal UC.

CALENDULA

Calendula is one of our best medical herbs. A randomized controlled trial looked at the ability of calendula tea retention enemas to promote colon mucosal healing in dogs with acetic acid-induced UC.5Although they did not carefully report details of benefit in the calendula vs placebo groups, the authors reported “significant mucosal healing” 1 month after the subjects received 7 days of calendula tea enemas. Since reading that report, I have used large-volume (half-liter or more) calendula tea retention enemas daily with quite a few patients with distal and proximal colonic IBD, some of whom have reported discernible decreases in rectal discharge of blood and/or mucus, as well as decreases in abdominal pain using this intervention.

Summary:
Large-volume calendula tea enemas may benefit some patients with active UC.

BUTYRATE

Butyric acid is a short-chain fatty acid generated by colonic bacteria. It is used in enema form to down-regulate inflammation and oxidative stress in the colon, which can be achieved even proximal to the sigmoid using only a 60 mL (100 mM butyrate) enema preparation.6 This decrease in inflammation may promote the tolerance of commensal microbes that is critically lacking in IBD.7

Early open-label and single-blind trials using butyrate enemas reported significant benefit in distal colitis8,9; however, later randomized controlled trials only reported significant benefit over placebo in some subgroups10 or for secondary endpoints,11 or found no benefit compared to placebo.12 I have not yet found butyrate enemas to offer significant benefit for my patients with UC, but I have only used them a few times, and other colleagues have reported meaningful benefit.

Summary:
There is conflicting data for small-volume butyrate enemas in the treatment of active distal colitis. Patients who have had IBD for <6 months and who have high compliance rates for this therapy may be the most likely to achieve benefits,10 including decreased bleeding and urgency.11

PROBIOTICS

Oral and rectal probiotics can help induce and maintain remission in patients with UC.13,14 In my experience, individual response to any given probiotic is highly idiosyncratic, so trial and error is my preferred approach to probiotic selection in IBD. That being said, several probiotic enema trials deserve mention, if nothing else to illustrate the point that probiotic enemas can be a useful intervention for UC patients.

In 1 trial, 5-aminosalicylic acid (5-ASA), alone or with oral Lactobacillus casei, failed to alter colon microflora; however, those interventions along with additional L casei enemas significantly altered colonic flora and Toll-like receptor expression and interleukin levels.15

Another group administered either Lactobacillus reuteri enemas (10 billion CFU per rectum QHS) or placebo enema for 8 weeks to 40 children with active distal UC.16 At 8 weeks, there was significant clinical and histological improvement in the probiotic group, vs no significant change in the placebo group. Clinical remission was reached in 31% of the probiotic enema group and in none of the placebo group.16

Many American clinicians are not familiar with the probiotic E coli Nissle 1917 (aka Mutaflor), which has been used in Europe for IBD and other conditions for almost 100 years. This is because the US Food and Drug Administration does not permit Mutaflor to be imported. Oral preparations compare favorably to mesalamine in achieving and maintaining remission when used in adults17 and children18 with active UC. Mutaflor enemas trend towards greater efficacy than placebo enemas for patients with moderately-active distal UC, with benefit increasing with increased volumes up to 40 mL.19

Bifidobacterium enemas have been given to successfully resolve necrotizing enterocolitis.20 This is not an autoimmune colitis like UC; however, it does demonstrate the ability of Bifidobacteria to safely and effectively alter colon flora to reduce dangerous inflammation.

I routinely prescribe Lactobacillus spp and Bifidobacterium spp probiotics enemas at doses of 10-500 billion CFU for patients with distal UC, and have found them to assist in inducing and maintaining remission.

Summary:
Probiotic enemas may help induce and maintain remission in patients with distal UC. Discovering the best species, dose, and frequency of administration for an individual patient will likely involve some individualized experimentation.

FECAL MICROBIOTA TRANSPLANTATION

Fecal slurry preparations, known as fecal transplant or fecal microbiota transplantation (FMT), have been used orally as “yellow dragon soup” to resolve intractable diarrhea since the 4th century in China.21Autologous and exogenous fecal-derived microbes have been administered via enema for UC and other conditions at least since 1910 in the United States.22 Whole-stool fecal slurry enemas have been used for infectious colitis since at least 1958.23 They have also been used by naturopathic doctors for IBD and other conditions in the United States since at least the 1970s,24 and are now used widely in North America for Clostridium difficile (C diff) infections not responding to standard therapies.25,26 When compared with colonoscopic and naso-duodenal delivery, FMT retention enemas have comparable or superior efficacy at resolving C diff infections.

A systematic review of case series of FMT for IBD, in general, reported a 76% response rate and 63% remission rate following FMT.27 A more recent and thorough systematic review and meta-analysis of FMT for IBD reported that 45% of IBD patients achieved clinical remission following FMT.28 A subgroup analysis of cohort studies demonstrated clinical remission in 22% of patients with UC.28

In an open-label trial, 10 children and young adults with mild-to-moderately active UC were given FMT retention enemas (average 165 mL) for 5 consecutive days.29 Of the 9 patients who were able to retain the enemas, 78% showed a clinical response at 1 week, 33% achieved remission at 1 week, and 67% retained their clinical response at 1 month.

Seventy-five active UC patients were randomized to receive weekly either an enema of 50 mL of FMT or a 50 mL water enema (control group) for 6 weeks.30 At 7 weeks, 24% of those in the FMT group were in remission vs only 5% of those in the placebo group. Stool donated by 1 particular donor led to remission in 39% of recipients, while stool from other donors led to remission in only 10% of the participants, suggesting statistical evidence for donor dependence. Participants with UC for less than 1 year were also significantly more likely to respond. There was no difference in adverse events between the FMT and control groups.30

In my practice, I’ve counseled hundreds of adults and children with IBD on the use of home FMT retention enemas. My observations are similar to those in the literature: following an initial series of one 4.5 oz FMT retention enema per day for 10 more-or-less-consecutive days, I see about a quarter of my patients with UC achieve remission, another half discernibly improve, and the last quarter experience no apparent benefit.

Summary:
FMT retention enemas cannot be prepared or administered by clinicians in North America for any patient other than those with C diff infections not responding to standard therapies31; however, many patients with UC turn to their clinicians for guidance around best practice for home FMT, and for stool donor screening. FMT retention enemas, used daily or weekly for 5 to 10 or more times, are significantly likely to lead to a clinical response, and have a 25% or greater chance of inducing remission within 6 to 10 administrations.

5-AMINOSALICYLIC ACID (5-ASA)

Mesalamine is the prescription 5-ASA (a salicylate derivative) most commonly used in IBD. It acts locally in the gut as a cyclooxygenase (COX)-inhibitor and antioxidant.32 Mesalamine preparations induce intolerance or hypersensitivity reactions in about 8% of patients with UC, and may rarely aggravate UC.33

Mesalamine enemas, used nightly for 12-34 weeks, appear to induce remission in the majority of patients with left-sided UC who are unresponsive or intolerant of other therapies.34 Mesalamine enema is equivalent or superior to oral mesalamine at inducing remission in patients with active left-sided UC, and oral and rectal mesalamine combined appears to be more effective than either individually.35 Mesalamine enema is equivalent (and non-significantly superior) to oral mesalamine at maintaining UC patients in remission.36 Mesalamine enemas may be safer in pregnancy and may have fewer side effects than oral preparations.37

Clinicians may think of mesalamine enema for the two-thirds of IBD patients whose disease is limited to the left side of the colon, but it also offers benefit for patients with disease that extends beyond the splenic flexure.38 The use of suppositories, rectal foams, or liquid enemas is based on the extent of the disease.

Efficacy of enemas does not appear to increase with doses over 1 mg.39 The most common mesalamine enema includes potassium metabisulfite as an inactive ingredient, but there is a sulfite-free version available for patients sensitive to sulfites.

Mesalamine enemas are significantly superior to corticosteroid enemas at inducing and retaining remission40; however, corticosteroid enemas may be indicated if other interventions including mesalamine enemas fail or if individual circumstances warrant.

Summary:
Mesalamine enemas, when used for >3 months at 1 mg per rectum QHS by patients who tolerate 5-ASA derivatives, are likely to induce and help maintain remission for many of the two-thirds of UC patients whose disease is mild or moderate and confined to the left side.

CORTICOSTEROIDS

Before corticosteroids were available, a first attack of UC was fatal about one-third of the time; now that number approaches 0.41 Corticosteroids induce partial or complete remission from IBD about 75% of the time,42 but potential side effects – including osteoporosis,43 osteonecrosis,44 and sleep and mood disturbances45 – limit its use. Corticosteroids are not helpful in maintaining long-term remission once it has been achieved, especially when used for longer than 3 months after induction of remission.46 In addition, as many as 9% of people with IBD may have a steroid allergy.47

In North America, the corticosteroids most commonly used for IBD are prednisone, hydrocortisone, and budesonide. The latter 2 are commonly used as enema preparations. Budesonide is a synthetic corticosteroid with low systemic availability due to high first-pass hepatic metabolism, so it has a greatly diminished side-effect profile.48 As many as one-half of IBD patients who don’t respond to mesalamine enemas may respond favorably to budesonide or hydrocortisone enemas,49 and twice-daily budesonide enemas lead to significantly more complete mucosal healing than once-daily enemas.50

Markers of bone formation fall rapidly within 5 days of starting oral corticosteroids; however, no decrease in bone formation markers occur within 2 weeks of starting prednisolone or hydrocortisone enemas.51

Patients tend to prefer foam over liquid enema preparations, though both are equally effective at inducing remission.52

Summary:
Corticosteroid enemas used for 6 to 8 weeks may induce remission in 50% or more of patients with left-sided UC not responding to 5-ASA enemas. Budesonide (2 mg per rectum BID) is the delivery method most likely to deliver the best outcome.

OTHER THERAPIES

There are other types of therapeutic retention enemas described in the literature for use in UC that I have not had the opportunity or additional training to appropriately use.

Historically, Chinese medicine did not use enemas as a delivery method for botanicals or other therapeutic substances53; however, in the past couple of decades, several authors have reported on the use of Chinese medicine herbal enemas to treat UC with varying degrees of efficacy.54-57 This treatment paradigm and the language of choice of these articles leave this author unable to appropriately assess the use of these therapies.

Alicaforsen, a prescription ICAM-1 inhibitor, given as an enema, is superior to placebo and equivalent to mesalamine enemas at inducing remission in patients with UC for up to 10 weeks, and is significantly superior to placebo and mesalamine at maintaining remission at 30 weeks in patients with moderately-to-severely active distal disease.58 Alicaforsen is approved as an orphan drug in Europe, but is not available in the United States.

A turmeric extract, standardized to 72% curcumin and given as a retention enema (140 mg of NCB-02 in 20 mL of water) QHS for 8 weeks, produced a trend towards more remission compared to placebo enema in patients with mild-to-moderate distal UC. Patients who completed all 8 weeks of therapy experienced significantly more remission (71%) than those in the placebo group (31%).59

Epidermal growth factor, a cytokine found in saliva, urine, and breast milk, given as 100 mL retention enemas (delivering 5 µg of epidermal growth factor) once nightly for 14 days, was able to induce remission in 10/12 patients with mild-to-moderate left-sided UC, whereas a placebo enema consisting of the same delivery medium led to remission in only 1/12.60 Unfortunately, no other groups have replicated these astounding results.

Nicotine retention enemas (3-6 mg nicotine for 4 weeks) may contribute to clinical improvement in patients with UC who don’t improve with corticosteroid or mesalamine enemas, albeit with some mild and transient adverse effects.61 However, they have not been found to induce remission more frequently than placebo enemas in broader UC patient groups.62 Nicotine is contraindicated for patients with CD.

Sodium hyaluronate (a mucosal hydrant and healer) enemas, given for 4 weeks, appear to be safe and may contribute to clinical response and mucosal healing in patients with distal UC.63

Rectal ozone may contribute to more rapid healing in patients with distal UC.64

Conclusion:
One-quarter of 1% of people in the United States have ulcerative colitis.65 For many of them with distal or more extensive colitis, retention enemas may be an excellent and underexamined method to deliver therapeutic liquids, including anti-inflammatory, vulnerary, and microbiota-altering substances. Knowing the value and advantages of these substances when delivered via enema may help clinicians and patients overcome the discomfort felt when talking about rectally-administered therapies.

Note: Originally published in January 2016 by Dr. Mark Davis ND and published NDNR – Naturopathic doctor News and Review, this article has been revised and updated for thoroughness. Dr. Mark Davis ND was interviewed for The Crohn’s And Colitis Summit

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Abdominal Pain CalProctetin Case Study Colonoscopy Colostomy Crohn's Disease Diversion colitis Enemas Fistula Hematochezia(Blood in Stool) Ileostomy Inflammation Pharmaceuticals Supplements Surgery Ulcerative Colitis

Coconut Oil Enemas Saves Woman From Surgery

A new case study* out of Germany was just published in the October 2018 American Journal of Gastroenterology.

A 32-year old woman was experiencing fistulizing Crohn’s Disease complicated with diversion colitis.  Diversion colitis is inflammation of the large intestine brought on after surgical treatment (Usually an ileostomy or colostomy).

In early 2016 her perianal fistula, after not responding to pharmaceutical drugs, was treated with a diverting sigmoidostomy which is when surgery creates an artificial anus in the sigmoid colon.  After the surgery, she initially responded well to ENTYVIO®(vedolizumab), although the symptoms from the fistula did not go away. Just a few months later in late 2016, symptoms increased. This included looser stools, increasingly worse abdominal pain(most patients refer to this as stomach pain), and increased mucus and blood.

“Joel Sprechman wasn’t around when I was diagnosed. If he was, with The Crohn’s and Colitis Summit, I am sure I would have avoided surgery.” – Summit Member

 

She switched to STELARA® (ustekinumab), which did not work for her, and also added topical hydrocortisone.  As this too failed, she tried REMICADE® (infliximab) and the chemotherapy drug Purinethol®(6-MP).  Unfortunately, the disease continued to worsen.  Because of the persisting fistula, a reversal of the sigmoidostomy was not an option. She also failed 5-ASA(Mesalamine usually sold as Asacol® HD, Pentasa®, Lialda™, Apriso®, or Delzicol™and glucocorticoids (Usually prednisone or prednisolone).  Her doctor’s next wanted to try short-chain fatty acid(SCFA) enemas as they have been shown to successfully treat colitis.[1][2] However, they were unable to find a compounding pharmacy offering this therapy.

Since she had failed at least five pharmaceutical options and experienced increasing symptoms of post-surgery, her doctors recommend a proctectomy. This would remove all or part of her rectum. She refused this option.

An October 2020 study found that surgery for Inflammatory Bowel Disease persistently lowers microbiome and metabolome diversity and further increased the instability in the gut microbiome of IBD patients.

I can understand this challenging decision, while some live (mostly) symptom-free post-surgery lives, many continue to experience shitty symptoms. Perhaps she was aware of the following statistics. Up to 75% of those with Crohn’s and up to 45% of those with Ulcerative Colitis will have surgery. Also, post-surgery recurrence rates are up to 60% with Crohn’s Disease and 50% with Ulcerative Colitis, and the fertility rates of women post-surgery are one-third of normal. These numbers are from a 2014 publication. [3]

The diagnosed rates of Inflammatory Bowel Disease have likely significantly increased since 2014. [4]

As she decided to refuse another surgery, she asked her doctors for an alternative option. 100ml of prewarmed Coconut Oil was recommended as a suspension enema. Coconut oil contains fatty acids with relatively short chain length to SCFA’s.[5]

coconut oil enema

Just one week into this alternative treatment, abdominal pain, and mucus in her stools decreased. After another six weeks, blood and mucus completely stopped! After 8 weeks of daily enemas, a sigmoidoscopy showed a clear improvement of inflammation(Both endoscopic and histologic).  After 12 weeks of treatment, all pain was gone, and she was able to return to work and resume physical activities up to four times a week!

Coconut Oil Enemas Saves Woman From Surgery #crohnsdisease #crohns #IBD #colitis Click To Tweet

She has continued daily enemas for 6 months with additional symptom reduction, without any adverse effects.

Endoscopic and histopathological findings of diversion colitis. Representative endoscopic images of the rectum prior (left) and after two (middle) and five (right) months of local coconut oil therapy. Before therapy, spontaneous bleeding, erosions, and fibrin indicated moderate mucosal inflammation. Follow-up endoscopies under treatment with coconut oil demonstrated only low-grade inflammation indicated by reduced vasculature and diffuse erythema.

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I contacted the authors of the study, who do not believe the type of Coconut Oil made a difference. I recommend Dr. Bronner’s organic virgin coconut oil in a glass jar.  I’ve met David Bronner and support their commitment to socially and environmentally responsible products. Like One Great Gut, they are also a B-Corp committed to social and environmental performance, accountability, and transparency. Their products do not contain any genetically modified ingredients/organisms (GMOs), are certified as kosher food, and are also vegan and never tested on animals.

Organic is important as you don’t want unwanted pesticides in your body, especially rectally where the bioavailability is higher. When medicine is delivered rectally it bypasses much of the body’s first-pass metabolism and will reach the circulatory system in greater concentration due to the higher bioavailability of rectal delivery. Glass is important for the same reason as you don’t want unwanted plastics that mix with the coconut oil in your body. Even BPA free plastic is not clean enough, it’s still a plastic you don’t want in your body. I’ve heard doctors refer to BPA-free as BPS(BP-“Sh#t”).

To deliver the coconut oil rectally, you can use an Enema bulb or a stainless steel enema bucket kit. The stainless steel enema bucket is the cleaner solution and allows you to re-use easily for other healing medicines like Slippery Elm, Vitamin E, Aloe Vera Juice, and Probiotics.   Most find the bulb to be more uncomfortable and more difficult to clean. I’d also recommend getting this protector pad. Great to protect your bedding or floors from any potential spills. The protector pad is waterproof, washable, and reusable.  I also used Organic Baby Wipes so you can clean your hand, fingers, and the tube as soon as you’re done.

Lab Testing

I recommend checking your Inflammatory markers throughout the year at regular intervals so you can track your progress. What gets measured gets managed. What gets managed can improve.

Inflammatory markers to track include Calprotectin, a stool test that measures inflammation in the gastrointestinal (GI) tract, C-Reactive Protein which is a blood test marker to test inflammation in the body, and Sed rate, also known as erythrocyte sedimentation rate ( ESR) which is also a blood test used to test inflammation in the body and help monitor the status of inflammation, progression or decline.

Your doctor can order these tests for you or you can order directly from the One Great Gut account at Ultra Lab Tests. This is the first company that not just lets patients order their own labs (and receive the results), but also allows you to submit your receipts to your insurance for billing! Please be sure to check with your insurance, as each company has different rules.

Using the links on this page will allow the lab companies listed below to donate to the One Great Gut Foundation.

Here are the direct links to the tests at Ultra Lab Tests for your convenience:

Sed Rate by Modified Westergren (ESR)
Useful in differentiating inflammatory and neoplastic diseases and as an index of disease severity. CRP is also useful in monitoring inflammatory disease states.

Calprotectin, Stool 
Calprotectin, Stool – Canada
Indicator of inflammation specifically in the GI tract. Clinical Significance Used to diagnose inflammatory bowel disease (IBD), including Crohn’s disease and ulcerative colitis, or to differentiate IBD from irritable bowel syndrome (IBS).

C-Reactive Protein Cardiac (hs-CRP)
Also useful in predicting risk for cardiovascular disease

Lactoferrin, Quantitative, Stool
This is an Enzyme-Linked Immunosorbent Assay (ELISA) for measuring concentrations of fecal lactoferrin, a marker for leukocytes. An elevated level is an indicator of intestinal inflammation. The test can be used as an in vitro diagnostic aid to distinguish patients with active inflammatory bowel disease (IBD) from those with noninflammatory irritable bowel syndrome (IBS).

Lactoferrin, Qualitative, Stool
The Lactoferrin IBD-CHEK® is a qualitative (QL) Enzyme Linked Immunosorbent Assay (ELISA) for measuring concentrations of fecal lactoferrin, a marker for leukocytes. A positive level is an indicator of intestinal inflammation. The test can be used as an in vitro diagnostic aid to distinguish patients with active inflammatory bowel disease (IBD) from those with non-inflammatory irritable bowel syndrome (IBS).

Fecal Globin by Immunochemistry (InSure®)
The fecal occult blood test is an immunochromatographic fecal occult blood test that qualitatively detects human hemoglobin from blood in fecal samples. This is a useful screening aid for detecting primarily lower gastrointestinal (G.I.) disorders that may be related to iron deficiency anemia, diverticulitis, ulcerative colitis, polyps, adenomas, colorectal cancers or other G.I. lesions that can bleed. It is recommended for use by health professionals as part of routine physical examinations and in screening for colorectal cancer or other sources of lower G.I. bleeding.

Fecal Globin by Immunochemistry (InSure®), Medicare Screen
The fecal occult blood test is an immunochromatographic fecal occult blood test that qualitatively detects human hemoglobin from blood in fecal samples. This is a useful screening aid for detecting primarily lower gastrointestinal (G.I.) disorders that may be related to iron deficiency anemia, diverticulitis, ulcerative colitis, polyps, adenomas, colorectal cancers or other G.I. lesions that can bleed. It is recommended for use by health professionals as part of routine physical examinations and in screening for colorectal cancer or other sources of lower G.I. bleeding.

Another good company to use is True Health Labs who offer more specialized testing. TrueHealthLabs, founded in 2009, was created by a Doctor to make lab testing directly available to those who are uninsured, underinsured, whose doctor refuses to order tests and those who simply want to make their own healthcare choices. Your results will be sent to you via encrypted email. Turnaround times are usually 3-4 business days, however, more complex tests can take 14+ business days.  TrueHealthLabs  saves you 20-80% off lab tests by negotiating directly with CLIA certified labs. With a very high trust rating from thousands of users I am a fan.

They conveniently accept HSA +FSA Accounts, too! 

Some of these tests are more expensive than your usual test, and that is because they give specific insight into certain lab markers that other labs are not able to see. For example, the last time I tested my

pro-inflammatory IL2-TH1 with lab corp they were only able to tell me that I was under 31.2. Not exactly helpful!! CytoDx, seen below, will show you IL2-TH1 with greater granularity, and since we would like it to be below 12, this further shows that the <31 from the other lab is not very useful information.

Antibodies to Saccharomyces cerevisiae
These are found in approximately 75% of patients with Crohn’s disease, 15% of patients with ulcerative colitis, and 5% of the healthy population. High antibody titers increase the likelihood of disease, especially Crohn’s disease, and are associated with more aggressive disease. As the inflammation in Crohn’s disease is focused at the gut mucosa, most patients have IgA antibodies to S cerevisiae and half of these also have IgG antibodies. A minority of patients have only IgG antibodies to S cerevisiae.

TH1 TH2 Cytokine Test – Basic
For those with a confirmed autoimmune condition, the Th1 Th2 test is possibly the most important test. The test points out imbalances in the immune system by looking at cytokines, proteins that the immune system relies on to communicate. Bad communication results in complications for those with autoimmune conditions. The information this test provides helps your doctor develop a strong and effective treatment plan for you, especially when seeking alternative medicine support.
The immune system works like a seesaw. On one side you have Th1 cytokines that initiate the first line of defense. On the other side, you have Th2 cytokines that help produce antibodies to protect you from future invasions. However, when one side goes up, the other side goes down. This can contribute to a weak immune system and potentially promote autoimmune issues. Running this test will help to understand where the imbalance is. Because certain botanicals used in natural medicine can boost Th1 cytokines and Th2 cytokines, this test can help you and your doctor develop an effective plan to help balance a weak immune system and turn the volume down on autoimmune attacks.

TH1 TH2 TH17 Cytokine Test – Advanced aka CytoDX
This test is more detailed than the above with readings including

  • Inflammatory Cytokines- Th1
    • INF Gamma: Th1
    • IL-1 beta: Th1
    • IL-2: Th1
    • IL-6: Th1 and Th2
    • IL-7: Weak Th1
    • IL-8: Weak Th1
    • IL-12 p70: Th1
    • IL-17A: Th17
    • IL-18: Weak Th1
    • TNF alpha- Th1
  • Anti-Inflammatory Cytokines- Th2
    • IL-4: Th2
    • IL-5: Th2
    • IL-10: T-regulatory cells
    • IL-13: Th2
    • IL-15: Weak Th2

TH17 Test
New studies show that an increase in a particular type of white blood cell, called Th17 cells, can trigger and determine the severity of autoimmune conditions. Monitoring Th17 levels can help you and your doctor better treat the condition.

Basic CD4 CD8 Ratio Test
The CD4 CD8 ratio profile helps assess the immune system in detail. This test is crucial for patients who are suspected of having a compromised immune system as seen in autoimmune conditions and HIV.

I recommend to run the Th1 Th2 test along with this CD4/CD8 ratio test if you have any concerns with an autoimmune condition like Crohn’s or Colitis.

We continually update the IBD Crohn’s Colitis Lab Testing Page You Can Order Without A Doctor. I recommend checking that page to see if there are any tests that may be helpful for your health journey.

Using the links on this page will allow the lab companies to donate to the One Great Gut Foundation.

I hope this has been helpful for your journey towards a Great Gut!

Have you tried a Coconut Oil enema? We’d love to hear from you. Your response can help others heal.  Please comment below, add your story to our research center, or leave us a comment on our Facebook page.

If you find this information useful, please donate so we can continue providing you with meaningful information to help you Thrive with IBD Crohn’s Colitis. Thank You.

References

[1] Harig JM, Soergel KH, Komorowski RA, et al. Treatment of diversion colitis with shortchain-fatty acid irrigation. N Engl J Med. 1989;320:23–28.
[2] Vernia P, Cittadini M, Caprilli R, et al. Topical treatment of refractory distal ulcerative colitis with 5-ASA and sodium butyrate. Dig Dis Sci. 1995;40:305–7
[3] CCFA 2014 Fact Book
[4] CDC Morbidity and Mortality Weekly Report (MMWR) – Prevalence of Inflammatory Bowel Disease Among Adults Aged ≥18 Years — United States, 2015 –  Published October 2016
[5] Orsavova J, Misurcova L, Vavra Ambrozova J, et al. Fatty acids composition of vegetable oils and its contribution to dietary energy intake and dependence of cardiovascular mortality on dietary intake of fatty acids. Int J Mol Sci. 2015;16:12871–90.
Case Study: The American Journal of Gastroenterology: Successful Long-term Treatment of Diversion Colitis with Topical Coconut Oil Application Dec 2018 : Zundler S, Dietz L, Matzel KE, Geppert CI, Becker E, Rath T, Neurath MF, Atreya R

Note: Originally published in October 2018, this article has been revised and updated for accuracy and thoroughness.

Categories
Crohn's Disease Gratitude Hospital Joel's Story LOVE Pharmaceuticals Relationships STORIES-OF-HOPE

Dear Doctor Bagley

I’m hopeful this is one way we turn around the broken healthcare system. I have a voice. You have a voice.

Express your appreciation for those who deserve it.

Also, express your dissatisfaction with those who deserve it. I also filed a formal complaint for one particular incident.

Don’t be that guy who only complains. Give honest feedback for extraordinary service. Extraordinarily bad, and extraordinarily good.

Hospitals take patient feedback seriously.

Together we can make a difference.

Dr. Bagley,

Just a quick note to say THANK YOU

You probably don’t remember helping me at UCSD Thorton IR on 2-11-2019 during my month long hospitalization. Your personal heartfelt patient centered care made a huge difference in my successful recovery, weeks ahead of Doctors prognosis. It was greatly appreciated, beyond what I can put into words here.

If you’re interested in the full story, I wrote about it on a public Facebook post here.

If what I wrote there can get you in trouble, please let me know and I’ll take it down as of course that is not my intention.

You may also appreciate this picture on the last day of my hospitalization 

I believe you’re a resident. Please keep your heart open for the years to come with patients. The one’s who allow the broken system to beat them down and lose empathy, compassion and forget why they become a doctor in the first place are all too common. You’re different, a unique unicorn that patients deserve more of. I can guarantee that other’s you help feel the same way, likely better, they just didn’t do the detective work I needed to do to locate your name in the 566 page report among the dozens of doctors who I saw that month.

Keep it up, you’re making a huge difference in “Making America Great Again”  Seriously!

With Gratitude,
Joel

PS – Who is your supervisor and how can I reach them, or is the WeListen hotline the best way to report your outstanding service?

Categories
Anxiety CalProctetin Crohn's Disease Depression DIAGNOSIS Emotional Inflammation LOVE Mood Changes Pharmaceuticals RESEARCH Resources Self Love Supplements SYMPTOMS The Crohn's And Colitis Summit TREATMENT Ulcerative Colitis

DMT May Rapidly Improve Depression, Anxiety, and Inflammatory Markers

According to a recent study[1] published in The American Journal Of Alcohol And Drug Abuse, 5-methoxy-N,N-dimethyltryptamine (5-MeO-DMT) may improve depression and anxiety when administered in a group setting.

In the Johns Hopkins University survey 80% of the participants found that the drug(medicine) improved anxiety and depression symptoms.

Studies show that a significant portion of those with IBD, Crohn’s Disease, Ulcerative Colitis suffer from depression and/or anxiety. [2]

I’d bet you a green smoothie that 100% of those with IBD have at some point suffered from depression and anxiety. I’d further bet you a mug of Bone Broth that 100% of humans have at some point experienced depression and anxiety.  It’s part of being human.

If you’ve met me you’d likely be surprised that even I have my bad days. But I do! I’ve given up before. I’ve had suicidal thoughts. I’ve texted the “crisis text line” looking for help.

I’ve also experienced DMT.  Once at a friends medical clinic. and once in a private ceremony. Both times were profoundly positive experiences. Both times I asked a lot of questions, and found myself extremely nervous beforehand – not knowing what to expert even though I’ve spoken to many who have, have done heaps of research, and have witnessed other’s experiencing DMT.

Everyone’s experience is different and I recommend only considering this with the right guidance and in the right setting.

DMT is a pretty hardcore psychedelic. It’s almost unbelievable that I would even consider taking a psychedelic as I grew up extremely against any illicit drugs, including marijuana though it was then legal in many states.

To make a long story short. I was diagnosed with IBD, experienced the horrendous side effects of Prednisone, and decided there must be a better way.  In my research I found Roman Hanis and Marcus, who both healed themselves from Crohn’s Disease and Ulcerative Colitis with outside-the-box alternative therapies.

I then learned of a government-sponsored study by professor Dr. David Nutt that showed the damage of certain drugs.

Then there was learning the history of marijuana prohibition and the healing of Justine Meader’s Crohn’s Disease through cannabis.

Each of these moments and thousands of other conversations opened up my mind to think about trying psychedelics for the first time.

I asked a friend about his DMT experience, this was his reply:

I’ve had to hold people down who were trying to sprint through a glass patio door, another person who was slamming his legs into the ground so hard he would have broken his heel had we not stopped him, etc… and people under the influence are 100% no conscious of what they’re doing.

I’ve never experienced anything remotely like that before, and though I’m usually a pleasantly positive person, I do feel intense anger and injustice on the inside at times.   As we learned from Dr. Vincent Pedre whom I interviewed for The Crohn’s And Colitis Summit – Autoimmune Disease is often anger turner inward.

One of the 5-MeO-DMT study authors, Joseph Peter Barsuglia had this to say:

My two cents (or 50 ; ) about our group scientific article on the sacred molecule, 5-MeO-DMT that made it into Medscape[3] and a few other sources last month…

The way the news surrounding this article spread is awesome. I do want to note that there was an omission of details about the context that is interesting and perhaps quite important. It appeared on the social media headlines that because the news came through Johns Hopkins School of Medicine, the study was conducted on individuals there, or conducted on a general survey of recreational users. Alan Davis was the fantastic primary author and is a research fellow at Hopkins, which is the reason for the affiliation.

However, what is essential is that the sample in this study were all initiates from a specific spiritual community who partook of this compound as a “sacrament”, only in group formats, and only in a ceremonial/ritualistic context.

The individuals who received the compound in this study were not explicitly seeking the medicine as a treatment for either depression or anxiety, although the majority reported improvements if they had a psychiatric history. This was not a treatment study or primarily an assessment of a clinical population. It was an observational study of “church” members of sorts.

These juicy tidbits did not make it into the news summaries in a clear way. An impressive percentage of individuals in this spiritual group who had prior diagnoses of depression and anxiety reported reductions in symptoms. However, for those who do know ; ) these phenomena are likely secondary byproducts of what is primarily a profound and rather reliable sacred/spiritual encounter.

I find this far more intriguing and perhaps relevant in some ways. The 5 can reduce depression and anxiety which is amazing, yet it is just barely scratching the surface of the infinite, as we are ; )

My sense is the capacity of this molecule to occasion spiritual awakening is what should be on the headlines, as I trust it will be in the near awakened future.

A little more detail on DMT: 

The medicine(drug) is extracted from the venom of The Colorado River Toad. The psychedelic experience typically lasts between 15 and 90 minutes depending on many factors including dosage, prior food and drink intake, and the type of DMT.

I wanted to write this quick blog to document what I believe to be a promising treatment for those seeking assistance with depression and anxiety.

Have you experienced DMT? Helpful? Harmful? Share your thoughts in the comments below so all may benefit from your experience.

First published in April 2019 this article has been updated for further accuracy.

References:
[1] The American Journal Of Alcohol And Drug Abuse – 5-methoxy-N,N-dimethyltryptamine (5-MeO-DMT) used in a naturalistic group setting is associated with unintended improvements in depression and anxiety –  Alan K. Davis PhD, Sara So MS, Rafael Lancelotta MS, Joseph P. Barsuglia PhD & Roland R. Griffiths PhD – Epub 2019 Mar 1

[2] Canadian Journal Of Gastroenterology and Hepatology – Prevalence of Anxiety and Depression in Patients with Inflammatory Bowel Disease  – Glynis Byrne, Greg Rosenfeld, Yvette Leung,  Hong Qian,  Julia Raudzus,  Carlos Nunez,  and Brian Bressler. Published online 2017 Oct 18

[3] ‘Toad Venom’ Psychedelic May Rapidly Improve Depression, Anxiety

[4] DMT: The Spirit Molecule: A Doctor’s Revolutionary Research into the Biology of Near-Death and Mystical Experiences by Dr. Rick Strassman

[5] Psychedelic drug 5-MeO-DMT induces rapid changes in inflammatory markers

[6] Psychopharmacology: Prospective examination of synthetic 5-methoxy-N,N-dimethyltryptamine inhalation: effects on salivary IL-6, cortisol levels, affect, and non-judgment, Malin V Uthaug, Rafael Lancelotta, Attila Szabo, Alan K Davis, Jordi Riba & Johannes G Ramaekers

 

 

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