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Malibu Microbiome Meeting

UPDATE: Postponed until August 22nd and 23rd

One of our volunteer advisers has been planning something special behind the scenes, and it’s finally around the corner…a continuing medical education(CME) event for both practitioners and patients.

Dr. Sabine Hazen MD, CEO of Ventura Clinical Trials, Malibu Specialty Center and Progenabiome is putting together a meeting of the minds.

Physicians, government, and industry share the latest in microbiome research, discoveries, and news on the gut flora and its role in dis-ease and healing potential.

Malibu Microbiome Meeting Dr. Borody Fecal Transplant FMT

Malibu Microbiome Meeting Conference
March 28 and 29 at Pepperdine University in the beautiful warm beach city of Malibu California.

WHO IS THIS FOR?

Patients, friends and family members who want to learn from the best of the best, tap into a collaborative supportive community and learn about evidence-based Integrative research and treatment options that normally take months or years to reach you while having a healthy fun time – yes this is for you.

Practitioners who want to connect with like-minded colleagues while learning about the latest clinical research, standards, and applications to elevate your toolbox and practice to a new level and be able to help more patients – yes this is for you

Researchers who want to connect with like-minded colleagues while learning about the latest findings to bring back to your clinic and further advance research which goes along with our Mission to HAMAPASAP – Help As Many As Possible As Soon As Possible

CME’s available

Because the World Needs Superheroes, These Doctors Work to Advance Medical Research and Save Lives

Expert Speakers Include:

Dr. Thomas Borody – from Centre for Digestive Diseases in Australia
Dr. Neil Stollman – UCSF / East Bay Center for Digestive Health
Dr. Sabine Hazen Progenabiome
Dr. Alex Khoruts – University of Minnesota
Dr. Colleen Kelly – Brown University
Dr. Yinghong Wang – MD Anderson Cancer Center
Dr. Paul Feurstadt – Yale School Of Medicine
Dr. Howard Young – National Institutes of Health(NIH)
Dr. Jessica Allegretti – Harvard Medical School
Dr. Sahil Khanna – Mayo Clinic

Christian Hundley / © TripSavvy

– Topics Include IBD Crohn’s, Colitis, Alzheimers, Autism, C.Diff, Cancer, Children, UTI and other applications

– Catering by Malibu Farms providing fresh, organic and local farm-to-table food

– Hootenanny For Healing with The Malibu Guitar Festival Saturday night w/ Live Music. Dinner. Drinks. Dancing. Fun Benefiting Microbiome Research Foundation @ Private Malibu Estate with Live Music from Brandon Jenner, The Kenneth Brian Band, and a special guest appearance we’re not yet at the liberty to announce 😉

Yes, that Jenner. Brandon’s parents are U.S. track and field Olympian Caitlyn Jenner and actress Linda Thompson. He is the brother of Brody Jenner, half-brother of Kendall, Kylie, and Burton Jenner, and Cassandra Marino. Brandon is now the ex-stepbrother of Kourtney, Kim, Khloé, and Rob Kardashian,

– Vendor Booths including Diagnostic Solutions Laboratory – Creators of GI-MAP and CytoDX. (Patients: You may now order these tests on your own here)

– Affordable pricing and for additional savings use code onegreatgut for 25% off + they have been kind to donate back to the One Great Gut Foundation for every ticket purchased using that code. So if you decide to attend you not only will receive the most advanced and up to date information about microbiome research and applications you’ll help us achieve our mission which is to help 10M Integratively Thrive with IBD,. Thrive Physically, Mentally, Emotionally and Spiritually.

NOTE:  One Great Gut does not promote or advocate for the clinical practices of the speakers as we are personally not familiar with their treatment recommendations, and more importantly, the results they are able to provide to their patients. We are promoting the Malibu Microbiome Meeting as a meaningful event to attend for up to the date scientific information and research. If you are looking for a vetted qualified practitioner you may consider the One Great Gut Network to help you Thrive. Many of the practitioners not only have IBD themselves but have fixed it, no longer suffer and now help other’s achieve those same results.

More on some of the speakers:

Professor Thomas Borody, founded the Centre for Digestive Diseases (CDD) in 1984 after a distinguished career with leading hospitals including St Vincent’s in Sydney and the Mayo Clinic in the USA.
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He is a world-renowned leader in the clinical microbiota dating back to 1988 when he started performing what is now called Fecal Microbiota Transplantation (FMT).
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The CDD has published 220+ scientific papers, treated 78,000+ patients, has 14+ inventions in market or trials, and Professor Borody holds over 150 patents in areas such as: treatment of Helicobacter pylori, Crohn’s disease, bowel lavage, IBS and FMT.

NEIL STOLLMAN, MD, FACP, FACG, AGAF

• medical degree: NYU School of Medicine
• residency: Columbia University – College of Physicians and Surgeons
• chief residency (Internal Medicine): Columbia University – College of Physicians and Surgeons
• fellowship (gastroenterology & advanced therapeutic endoscopy): University of Miami School of Medicine
.
An expert in C difficile infection and fecal transplantation, diverticular disease and H pylori, Dr. Stollman has published his work in journals such as Lancet, Gastroenterology, the American Journal of Gastroenterology, and Gastrointestinal Endoscopy.
.
He has served on the American Gastroenterological Association Research and Clinical Guidelines Committees, the American College of Gastroenterology Educational Affairs, Patient Care, and Credentialing Committees and the Editorial Advisory Board of Gastrointestinal Endoscopy.
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Dr. Stollman is also a Fellow of the American Gastroenterological Association (AGA) and the American College of Gastroenterology (ACG). He is currently the Chairman of the ACG Board of Governors.
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He is currently an Associate Clinical Professor of Medicine at UCSF, Chief of the Division of Gastroenterology at Alta Bates Summit Medical Center in Oakland, and prior Chief of Gastroenterology at the Miami VA Medical Center and San Francisco General Hospital.

PAUL FEUERSTADT, MD, FACG, AGAF
• medical degree: Weill Medical College of Cornell University
• residency: New York Presbyterian Hospital
• fellowship: Montefiore Medical Center-Albert Einstein College of Medicine
.
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Throughout Dr. Feuerstadt’s career he has been involved in research and other academic pursuits. His research focuses include fecal microbiota transplantation, Clostridioides difficile infection, irritable bowel syndrome and ischemic bowel disorders. He has presented his research extensively and has authored and co-authored many manuscripts and textbook chapters.
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Another passion of Dr. Feuerstadt’s is teaching, frequently giving lectures locally, regionally, nationally and internationally and mentoring the fellows in the Division of Digestive Disease at Yale-New Haven Hospital where he is an Assistant Clinical Professor of Medicine.
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We are honored to have Dr. Feuerstadt speaking on “Challenges Around Clinical Trials in C.difficile” at the Malibu Microbiome Meeting on March 28-29, 2020
.

 

Categories
Abdominal Bloating Abdominal Pain Anxiety Arthritis Constipation Crohn's Disease Depression Diarrhea Fistula Gas-Flatulence Hemorrhoids LOVE Moonface Pain Relationships Self Love Sex Stomach Ache SYMPTOMS TREATMENT Ulcerative Colitis

How Deep Is Your Love?

HOW DEEP IS YOUR LOVE?

Can you love your perceived flaws?

Can you love your pain and suffering?

Can you love the darkest aspects of yourself?

Can you love those that don’t love you back?

Can you love ALL of your ex-partners? In-Laws and  Out-Laws?

Can you love those who you strongly disagree with?

Can you love those that judge you?

Can you love the ugly?

Can you love the ignorant?

Can you love everyone who is an “-ist?”


Can you love the psychopathic?

Can you love the depraved?

Can you love the murderous?

Can you love the genocidal?

Can you love your IBD, Crohn’s, Colitis, Arthritis, Osteoporosis, microscopic colitis, hemorrhoids, and skin tags?

Can you love any anxiety, depression, or lack of energy?

Can you love your first surgery?

Can you love your J-Pouch?

Can you love your Ostomy?

Can you love your Colostomy?

Can you love your “Barbie Butt”?

Can you love your last surgery?

Can you love your gut?

Can you love your colon?

Can you love the parts of your colon you still have left?

Can you love the fact that you may no longer have a colon?

Can you love the surgeon, gastroenterologist, nurse and registered dietitian regardless of what they said or did?

Can you love the Integrative Medicine Doctor, Functional Medicine Coach, Doctor Of Osteopathy, Health Coach, Consultant, Acupuncturist, Chiropractor, Naturopathic Physician,  Naturopath and Massage Therapist – regardless of the results?

Can you love your flatulence, gas, constipation, diarrhea and any other embarrassing symptoms you may be feeling today or have in the past?

Can you love the fissure, fistula, abscess, and pain?

Can you love your Colonoscopy, MRI, MRI, Endoscopy no matter what the results show?

Can you love those who you wish were more supportive of your journey?

Can you love those that you feel abandoned by?

Can you love your sex drive, libido, vaginal wetness and morning wood wether it’s there, or not?

Can you love your moon-face, excess or under weight?

Can you love those that you feel hurt you?

Can you love yourself for the times you said those things that you didn’t really mean?

The strength, depth, breadth, commitment, and unconditionality of your love is the key determinant of your spiritual evolution.

Love doesn’t mean you condone someone’s actions.

Love doesn’t mean accepting what-is and giving up on consciously, intentionally, and mindfully moving forward.

Can you love your life regardless of circumstance?

This isn’t ordinary love.

This is radical, infinite love, which I know deep in my heart that we are all capable of.

We all come from infinite love and are all returning to it.

Humanity has been living by the maxim, “If we hate it enough, it will just go away.”

That approach does not, cannot, and will never work.

What we resist will persist.

The ONLY way out is through.

And the only way through is love

What if Rumi was right – “Thorugh love, all pain will turn to medicine”

Inspired by Lars King

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Accidental Fear or Valid reporting? Risk of New IBD Rises for Patients Treated With Etanercept

The Center for Biosimilars today published an article that concluded that there is a fearful risk of being diagnosed with IBD Crohn’s or Colitis for those currently being treated with Etanercept.

Respectfully, I believe this study is incomplete and does not tell the full story. Though I don’t currently have access to the full study, just the Wiley Online Library Summary and the Center for Biosimilars article, until Lifestyle and Diet are factored into these studies I believe they do not tell the complete story.  20 years of clinical and cost outcomes from Integrative Medicine* have demonstrated the following results:

60% Decrease in hospital admissions
59% Reduction in hospital days
62% Savings in Outpatient surgeries and procedures
85% Reduction in Pharmaceutical costs
*Data provided by Patient-centered integrative medicine Independent Practice Association (IPA) per Advanced Medicine Integration Group, L.P. (AMI)

With the efficacy of leverage of using Integrative Medicine Lifestyle and Dietary changes, and the rise of it’s usage I believe a study like this is incomplete and may be unintentionally promoting accidental fear. What do you think?

Combined with the recent news that the United States Congress is grappling with tainted Chinese drugs, baffled by lack of FDA oversight in the U.S. pharmaceutical supply chain*. Remember when lead paint in children’s toys were a problem? That’s nothing compared to my concern to FDA Approved drugs potentially containing unwanted excipients.

As shown by the patients I interviewed during the Crohn’s And Colitis Summit who believe they are now cured of IBD Crohn’s and Colitis it’s becoming increasingly apparent for all of us to pay attention to our Physical, Mental, Emotional and Spiritual healing and growth.

Etanercept is a biopharmaceutical that treats autoimmune diseases by interfering with tumor necrosis factor by acting as a TNF inhibitor. It has U.S. F.D.A. approval to treat rheumatoid arthritis, juvenile idiopathic arthritis and psoriatic arthritis, plaque psoriasis and ankylosing spondylitis.

They state that while anti-tumor necrosis factor (anti-TNF) drugs are effective at treating a range of inflammatory diseases, some limited data suggest that they may, paradoxically, result in a higher risk of developing other de novo inflammatory conditions.

It’s worth mentioning that anti-TNF drugs are not the only drugs available to those with inflammatory diseases. Recently the United States FDA approved Stelara for ulcerative colitis. It’s also important to note that there are different inflammatory markers in the body. TNFa is only one of those markers. When my TNFa was low, I failed Remicade. Though this was the recommendation of my then specialist Doctors, it seemed apparent to me that I would fail Remicade, and subsequently, I did. This resulted in a horrific QOL(Quality of Life) and a very small regretful view of the world and shitty symptoms.  In hindsight, I should never have tried Remicade knowing that my TNFa was within the normal range. If you are wondering what your inflammatory markers look like I recommend ordering a test from this page: IBD Crohn’s Colitis test you can order from home.

Recently, Danish researchers sought to assess whether there is a link between anti-TNF therapy and the development of inflammatory bowel disease (IBD).1 Using nationwide Danish registries, the group examined data for all patients with rheumatoid arthritis, psoriasis, psoriatic arthritis, ankylosing spondylitis, pemphigus, alopecia areata, and vitiligo who were enrolled between 1994 and 2017. Anti-TNF agents were introduced in Denmark in 2004, and there were 17,018 individuals who had been exposed to anti-TNF drugs and 63,308 who had not been exposed.

Overall, 7344 patients were treated with infliximab, 9072 were treated with etanercept, and 8355 were treated with adalimumab. Fewer patients were treated with golimumab (n = 1973) or certolizumab pegol (n = 2503). Overall, 34.1% of patients were exposed to 2 anti-TNF drugs, and 16.7% were exposed to 3 or more.

The researchers found that patients treated with etanercept had a significant increase in the risk of developing new Crohn disease (CD), with an adjusted hazard ratio (HR) of 2.0 (95% CI, 0.8-2.2). The adjusted HRs for developing CD were 1.3 (95% CI, 0.8-2.22) for infliximab and 1.2 (95% CI, 0.8-1.8) for adalimumab. There was no statistically significant increased risk for new CD with golimumab or certolizumab pegol.

Additionally, patients treated with etanercept had a significant increase in the risk for developing new ulcerative colitis (UC), with an adjusted HR of 2.0 (95% CI, 1.5-2.8). The adjusted HRs for developing new UC were 1.0 (95% CI, 0.6-1.6) for infliximab and 0.6 (95% CI, 0.3-1.0) for adalimumab. Again, there was no statistically significant increased risk for new UC with golimumab or certolizumab pegol.

According to the authors, “This study firmly establishes the risk of developing de novo IBD while on anti‐TNFα agents, particularly with etanercept.”

In a letter linked to the publication, a separate group of authors from the centers in China noted that a different TNF binding pattern may be responsible for the increased risk of new IBD with etanercept versus other anti-TNFs.2

Etanercept binds to 2 of 3 sites of the TNF molecule, while infliximab binds to all 3, they explain. Additionally, unlike infliximab or adalimumab, etanercept does not bind to peripheral blood cells and lamina propria mononuclear cells derived from patients with IBD. Infliximab and etanercept also have different effects on cytokine production of T lymphocytes, “possibly inducing IBD in genetically predisposed patients,” say the authors, adding that more research into IBD-triggering pathways is warranted.

Lessons Learned:

If you’re unsure which pro-inflammatory markers are high in your body, consider your options here: IBD Crohn’s Colitis test you can order from home. Doctor approval is direct from the companies listed, you do not need to obtain prior approval from your personal Doctor, which can lead to unwanted delays, or being denied to have the blood test you wish to see the results of for your body to make the most educated decision for your health.

Any purchase from the lab test companies on that page, or the below links will allow the One Great Gut Foundation to get closer to meeting our initiatives which help you Thrive with IBD Crohn’s and Colitis. So you can invest in your health and build a healthier world through our initiatives, at the same time. Thrive Physically, Mentally, Emotionally and Spiritually.

Monitoring your health. The Crohn’s Disease Activity Index (CDAI) and the Simple Clinical Colitis Activity Index (SCCAI) are useful tools to consider using.  They access disease activity in Crohn’s and Ulcerative Colitis. For children, consider the Pediatric Crohn’s Disease Activity Index(PCDAI ) or Pediatric Ulcerative Colitis Activity Index (PUCAI).

Lab Tests to Consider

TH1 TH2 Cytokine Test – Basic
For those with a confirmed autoimmune condition, the Th1 Th2 test is possibly the most important test. The test points out imbalances in the immune system by looking at cytokines, proteins that the immune system relies on to communicate. Bad communication results in complications for those with autoimmune conditions. The information this test provides helps your doctor develop a strong and effective treatment plan for you, especially when seeking alternative medicine support.

The immune system works like a seesaw. On one side you have Th1 cytokines that initiate the first line of defense. On the other side, you have Th2 cytokines that help produce antibodies to protect you from future invasions. However, when one side goes up, the other side goes down. This can contribute to a weak immune system and potentially promote autoimmune issues. Running this test will help to understand where the imbalance is. Because certain botanicals used in natural medicine can boost Th1 cytokines and Th2 cytokines, this test can help you and your doctor develop an effective plan to help balance a weak immune system and turn the volume down on autoimmune attacks.

TH1 TH2 TH17 Cytokine Test – Advanced aka CytoDX
This test is more detailed than the above with readings including

  • Inflammatory Cytokines- Th1
    • INF Gamma: Th1
    • IL-1 beta: Th1
    • IL-2: Th1
    • IL-6: Th1 and Th2
    • IL-7: Weak Th1
    • IL-8: Weak Th1
    • IL-12 p70: Th1
    • IL-17A: Th17
    • IL-18: Weak Th1
    • TNF alpha- Th1
  • Anti-Inflammatory Cytokines- Th2
    • IL-4: Th2
    • IL-5: Th2
    • IL-10: T-regulatory cells
    • IL-13: Th2
    • IL-15: Weak Th2

TH17 Test
New studies show that an increase in a particular type of white blood cell, called Th17 cells, can trigger and determine the severity of autoimmune conditions. Monitoring Th17 levels can help you and your doctor better treat the condition.

Basic CD4 CD8 Ratio Test
The CD4 CD8 ratio profile helps assess the immune system in detail. This test is crucial for patients who are suspected of having a compromised immune system as seen in autoimmune conditions and HIV.

Any purchase from the lab test companies above using the above links will allow the One Great Gut Foundation to get closer to meeting our initiatives which help you Thrive with IBD Crohn’s and Colitis. So you can invest in your health and build a healthier world through our initiatives, at the same time. Thrive Physically, Mentally, Emotionally and Spiritually.

References
1. Korzenik J, Larsen MD, Nielsen J, Kjeldsen J, Norgard BM. Increased risk of developing Crohn’s disease or ulcerative colitis in 17,018 patients while under treatment with anti‐TNFα agents, particularly etanercept, for autoimmune diseases other than inflammatory bowel disease. Aliment Pharmacol Ther. 2019;50(3):289-294. doi: 10.1111/apt.15370.

2. Dai C, Jian M, Sun MJ. Letter: increased risk of developing Crohn’s disease or ulcerative colitis in 17 018 patients while under treatment with anti‐TNFα agents, particularly etanercept, for autoimmune diseases other than IBD. Aliment Pharmacol Ther. 2019;50(7):834-835. doi: 10.1111/apt.15460.

3. AP&T – Alimentary Pharmacology and Therapeutics – Increased risk of developing Crohn’s disease or ulcerative colitis in 17 018 patients while under treatment with anti‐TNFα agents, particularly etanercept, for autoimmune diseases other than inflammatory bowel disease – Joshua Korzenik Michael Due Larsen Jan Nielsen Jens Kjeldsen Bente Mertz Nørgård First published: 02 July 2019 https://doi.org/10.1111/apt.15370  The Handling Editor for the article was Professor Richard Gearry, and it was accepted for publication after full peer‐review. Funding information: University of Odense Hospital Free Research Foundation.

* Newsweek October 2019 Congress grappling with tainted Chinese Drugs, is baffled by lack of FDA oversight in U.S. Pharmaceutical supply chain by Blake Dodge
https://www.newsweek.com/congress-spooked-tainted-chinese-drugs-eyeing-pharmaceutical-supply-chain-1468753?fbclid

* Newsweek December 2019 U.S. DRUG PRICES TO RISE IN 2020 AS COMPANIES PREPARE TO CHARGE MORE FOR IBRANCE, XELJANZ, 200 OTHERS by Jeffrey Martin
https://www.newsweek.com/us-drug-prices-rise-2020-companies-prepare-charge-more-ibrance-xeljanz-200-others-1479939

Categories
Case Study DIAGNOSIS EAT Herbal Medicine Nutrition Pharmaceuticals Recipies Resources STORIES-OF-HOPE The Crohn's And Colitis Summit

The Crohns Colitis Summit Changed My Life. Don’t give up the good fight! You are bringing so much healing to the world….

…that’s what Mia emailed me. After asking her to elaborate, this is what she said next:

I have rheumatoid arthritis. I got diagnosed at the end of 2016, with a 4 months wait to see a rheumatologist, on state insurance because I wasn’t able to work from the pain and fatigue, and with Trump attacking the ACA I was terrorized over the idea of being dependent on the US medical system and then being denied coverage.
I decided to seek further education in proactive healthcare I could rely on. I spent that time doing AIP to see if anything besides gluten was triggering my flares and researching anything holistic or lifestyle-related that I could try to help my symptoms. I was terrified of pharma, and putting off trying it. My rheumatologist was hitting the scare tactics pretty hard, so I didn’t really trust him. But they were ok monitoring my attempts with the diet etc. And just checking in every 4 months. They had nothing to offer me except to take the meds and no real dialogue about the medications.

Note: For credible AIP information check out The Alternative Autoimmune Cookbook: Eating for All Phases of the Paleo Autoimmune Protocol by Angie Alt and the SAD to AIP in SIX online course which runs a few times a year.

I signed up dor anything autoimmune-related because I realized that was the better diagnosis. Sticking to RA focused information isolated me from a larger pool of information. So I signed up for the Crohns And Colitis Summit. And I saw you had an interview with Dr. Konijeti about medication. I trusted her input because she led that study on the AIP diet. Your interview questions were SO good and her answers were equally valuable. After that interview, all my questions about medication were touched on, and I felt better about trying pharma. I also noticed in the interviews with people who are controlling their AI without medication, there was a common pattern. They used pharma to break the inflammation cycles and get to a place where they could maintain their status quo without the medication.
I’m now 14 months pain-free. 20 months on medication. We’re planning to start trying to conceive my first child next month. Which was my dearest dream for getting my RA under control.
I’ve learned so much. A big one no one talks about is how autoimmune diseases are often catabolic that means recovery and ramping down the immune system includes expected weight gain as the metabolism adjusts. For a woman, that is terrifying in our society. Its a huge fear for us in everyday situations, and will stop a woman from continuing treatment.
Its been a wild 2 years. Your summit was a big turning point in my approach to treatment. By the time I started meds, I was a peace with it, and I think that absolutely contributed to how fast my first medication worked for me.
So. Thank you.
Mia Maria Siler
Categories
Case Study Crohn's Disease DIAGNOSTIC TESTING MOVE Relationships RESEARCH Stories STORIES-OF-HOPE

Cured Of Crohn’s? That’s what Joshua states

Joshua is CURED of Crohn’s!?!?

Interview with Joshua Nachman, MS, CNS, LDN, CPT

Brought To You By The One Great Gut Foundation

One Great Gut Foundation Purpose: We teach our community how to Thrive with IBD Crohn’s Colitis by working together to accelerate healing, reverse dis-ease, and bring on the super poops that everyone deserves.

Fun fact: A super poop is an ideal donor for a Fecal Transplant, arguably the world’s best probiotic.

In other words – it’s good shit. Literally!

Joshua is the owner of Balanced Bodies Balanced Minds and holds a Master of Science in Nutrition and Integrative Health from the Maryland University of Integrative Health. He has instructed nutrition classes at the Maryland University of Integrative Health and Stratford University. He worked as an integrative nutritionist at the Johns Hopkins Integrative Medicine and Digestive Center .

Now he facilitates healing for all who ask both remotely and in-person.

And now as a member of the One Great Gut Network, he offers his clients deep discounts if you use the code onegreatgut.

In addition, to those that use the onegreatgut code, he will generously donate 20% of every consult to the One Great Gut Foundation as we improve the lives of those living with Crohn’s and Colitis. We are the community cure for IBD.

Today Joshua is a clinical nutritionist who fully healed his Crohn’s through food, nutrition and “Spirit” – who now helps others do the same

He also genetically healed his IBD through one of our four pillars – “Spirituality”. God / Universe allowed his offending genes to be turned off.

Too good to be true?

A con artist?

A truth-teller?

Find out for yourself. I recorded this interview in the One Great Gut Support Group: Integrative Healing Of Crohn’s, Colitis & IBD! Private Facebook group.

Cost: Donation to One Great Gut Foundation (Optional)

 

Categories
Biologics C-reactive protein (CRP) CalProctetin Colonoscopy Crohn's Disease Nutrition One Great Gut Collection Pharmaceuticals RESEARCH Resources STORIES-OF-HOPE The Crohn's And Colitis Summit TREATMENT Ulcerative Colitis

US FDA approves Stelara for ulcerative colitis

Do you find these articles helpful? Please donate today so we may continue this service so humanity may prosper in a peaceful world with a peaceful microbiome

This past October, the U.S. Food and Drug Administration approved ustekinumab (Stelara by Janssen), a human IL-12 and IL-23 antagonist.

This is based on data from a phase 3 UNIFI trial, which demonstrated that ustekinumab induced and maintained clinical remission in a significantly greater proportion of adults with moderately to severely active UC compared with placebo.

Trial And Study Results

Janssen said at the time the UNIFI data was released that at Week 8, the trial data showed Stelara hit some of its major secondary endpoints, which includes the proportion of patients in clinical response, endoscopic healing, as well as health-related quality of life scores. In addition, Janssen said that at least 50 percent of study participants were considered biologically refractory, and 17 percent had a history of inadequate response or intolerance to any anti-TNF antibody and Takeda’s Entyvio (vedolizumab). It is unknown if diet and lifestyle were tracked in these studies.

Stelara, Janssen said, is the first and only approved biologic therapy for UC that targets the interleukin (IL)-12 and IL-23 cytokines. The IL-12 and IL-23 cytokines have been shown to play an important role in inflammatory and immune responses.

The UNIFI trial includes an initial induction study and was followed by a maintenance study eight weeks later where patients received subcutaneous injections of Stelara every 8 weeks for 44 weeks. In the Induction study, 19% of patients receiving Stelara achieved clinical remission in 8 weeks. Janssen also noted that Stelara provided rapid relief of symptoms as 58 percent of patients experienced a clinical response at Week 8. It is not known what diet or lifestyle factors were being implemented by the patients during the study

In the maintenance study, 45% of patients who received Stelara remained in remission after one year. Stelara also helped patients achieve clinical remission without the use of corticosteroids, the company noted. At the end of the first year, 43% of patients treated with Stelara were in clinical remission and not receiving steroids, Janssen said. At the risk of sounding repetitive, it is not known what diet or lifestyle factors were being implemented by the patients during the study. Not the downplay the efficacy and results of these studies and trials, we know from both the Crohn’s And Colitis Summit and One Great Gut Collection that Diet and Lifestyle alone can induce long term remission, deep mucosal healing sometimes confirmed by visual examination via Colononsocopy per the patient request, sometimes simply confirmed by a high Quality of Life, Thriving lifestyle, and lack of debilitating symptoms

In addition to the latest approval from the FDA, Stelara has been approved as a treatment for adults living with moderate to severe plaque psoriasis, adolescent patients with moderate to severe plaque psoriasis, adults with active psoriatic arthritis and adults with moderately to severely active Crohn’s disease. The drug brings in about $4 billion in annual sales which shows the need for this drug in today’s current environment and the additional need for Dietary and Lifestyle guidance.

If you’re unsure which pro inflamantroy markers are high in your body, consider your options here: IBD Crohn’s Colitis test you can order from home. Doctor approval is direct from the companies listed, you do not need to obtain prior approval from your personal Doctor, which can lead to unwanted delays, or being denied to have the blood test you wish to see the results of for your body to make the most educated decision for your health.

Monitoring your health. The Crohn’s Disease Activity Index (CDAI) and  Simple Clinical Colitis Activity Index (SCCAI) are useful tools to consider using.  They access disease activity in Crohn’s and Ulcerative Colitis. For children, consider the Pediatric Crohn’s Disease Activity Index(PCDAI ) or Pediatric Ulcerative Colitis Activity Index (PUCAI).

Lab Tests to Consider

TH1 TH2 Cytokine Test – Basic
For those with a confirmed autoimmune condition, the Th1 Th2 test is possibly the most important test. The test points out imbalances in the immune system by looking at cytokines, proteins that the immune system relies on to communicate. Bad communication results in complications for those with autoimmune conditions. The information this test provides helps your doctor develop a strong and effective treatment plan for you, especially when seeking alternative medicine support.

The immune system works like a seesaw. On one side you have Th1 cytokines that initiate the first line of defense. On the other side, you have Th2 cytokines that help produce antibodies to protect you from future invasions. However, when one side goes up, the other side goes down. This can contribute to a weak immune system and potentially promote autoimmune issues. Running this test will help to understand where the imbalance is. Because certain botanicals used in natural medicine can boost Th1 cytokines and Th2 cytokines, this test can help you and your doctor develop an effective plan to help balance a weak immune system and turn the volume down on autoimmune attacks.

TH1 TH2 TH17 Cytokine Test – Advanced aka CytoDX
This test is more detailed than the above with readings including

  • Inflammatory Cytokines- Th1
    • INF Gamma: Th1
    • IL-1 beta: Th1
    • IL-2: Th1
    • IL-6: Th1 and Th2
    • IL-7: Weak Th1
    • IL-8: Weak Th1
    • IL-12 p70: Th1
    • IL-17A: Th17
    • IL-18: Weak Th1
    • TNF alpha- Th1
  • Anti-Inflammatory Cytokines- Th2
    • IL-4: Th2
    • IL-5: Th2
    • IL-10: T-regulatory cells
    • IL-13: Th2
    • IL-15: Weak Th2

TH17 Test
New studies show that an increase in a particular type of white blood cell, called Th17 cells, can trigger and determine the severity of autoimmune conditions. Monitoring Th17 levels can help you and your doctor better treat the condition.

Basic CD4 CD8 Ratio Test
The CD4 CD8 ratio profile helps assess the immune system in detail. This test is crucial for patients who are suspected of having a compromised immune system as seen in autoimmune conditions and HIV.

Any purchase from the lab test companies above using the above links will allow the One Great Gut Foundation to get closer to curing IBD Crohn’s and Colitis. So you can invest in your health and build a healthier world through our initiatives, at the same time.

Stelara Efficacy and Frequency

Many of us are already familiar with the efficacy and safety of ustekinumab in Crohn’s disease given that it has been commercially available for more than 3 years now,” Edward V. Loftus Jr., MD, Chief Medical Editor of Healio Gastroenterology and Liver Disease, said in an interview. The approval was based on the UNIFI induction and maintenance trials, which was published late last month in The New England Journal of Medicine. Along with the usual endpoints, ustekinumab was found to be significantly more effective than a placebo at inducing and maintaining a combined endpoint of both endoscopic and histologic improvement.”

The first dose of ustekinumab will be administered intravenously in a health care facility. After that, the remaining doses will be given subcutaneously 8 weeks after the first dose and then every 8 weeks thereafter. Sometimes varying frequencies outside of the 8-week window is needed. I know of patients who are approved to take ustekinumab every 6 or 7 weeks to manage their symptoms.

Lifestyle and Diet

In many patients, diet and lifestyle changes have increased the success of ustekinumab and decreased unwanted side effects. To learn about the most effective dietary and lifestyle techniques that worked for other’s who found full remission, some claiming they are cured, with evidence-backed by Colonoscopy which showed no sign of IBD, ever. As a matter of fact the Gastroentrolgist stated that if the patient had not let him know that they previously had a challenging case of Crohn’s or Colitis, they would never have known. ref: Crohn’s And Colitis Summit and One Great Gut Collection

Remember, what works for one may not work for another. I recommend that you allow Science to be your map, and intuition to be your compass. We’ve noticed that healing is accelerated when the patient heals themselves not just Physically, but also Emotionally, Mentally and Spiritually.  As a matter of fact I’ve interviewed some who claim to be cured, simply by doing the work mentally(Paul), or spiritually(Joshua).

Look, You didn’t get into this alone, and you aren’t getting out of it that way, either. Join this community and your poops will soon shine. Friends don’t let friends suffer alone.

I’ve been Thriving with IBD since 2019

Are you looking for more information on how you too can Thrive with IBD? Join our email list(No Spam, No nonsense, no longer daily, just useful updates) and follow us on Instagram(@onegreatgut) Twitter and Facebook. I’m also on TikTok and Snapchat but don’t post there often and have no idea what I’m doing there except enjoying the creativity of the next generation. Does anyone want to help me out there?

Do you find these articles hgelpful?  Please donate today so we may continue this service so humanity may prosper in a peaceful world with a peaceful microbiome

Note: Originally published in December 2019, this article has been revised and updated for accuracy and thoroughness.

Ref:
Healio Gastroenterology and Liver Disease
Biospace – Janssen’s Stelara Wins FDA Approval for Ulcerative Colitis

 

 

 

Categories
Biologics Crohn's Disease DIAGNOSTIC TESTING Pharmaceuticals RESEARCH TREATMENT

Researchers discover critical link to controlling inflammation in Crohn’s disease

To aggregate the most appropriate IBD news we are republishing this article. This was first reported by Case Western Reserve University in MedicalXpress. We updated the article for further accuracy.
(Thank You Dr. Peter Spiegel for bringing this breakthrough to our attention)

Investigators at the Case Western Reserve University School of Medicine discovered that blocking interleukin-1α (IL1α), a protein that controls inflammation in the gut, markedly decreases the severity of intestinal inflammation in a mouse model of Crohn’s disease (CD).

The anti-inflammatory effects of the biological therapies used to neutralize IL1α were similar to those of steroids, which represent what is generally considered the gold standard of treatment for these patients. In addition, the researchers found that the effect of anti-IL1α treatment was controlled by changing the composition and function of the gut microbiome.

Their findings will be published online the week of Dec. 16 in the Proceedings of the National Academy of Sciences.

“This is one of the first studies, to our knowledge, that links the effect of a specific cytokine, such as IL1, to the gut microbiome,” said lead author Fabio Cominelli, professor of medicine and pathology at Case Western Reserve University, and division chief of gastroenterology at University Hospitals Cleveland Medical Center.

Furthermore, the study provides the preclinical rationale for performing the first clinical trial blocking interleukin-1 in patients with inflammatory bowel disease (IBD), which Cominelli and his collaborators at Xbiotech Inc., a biosciences company based in Austin, Texas, who developed a human monoclonal antibody against IL1α, are planning for the near future.

“I’m really excited about this study because I started my career three decades ago collaborating with (co-author) Dr. Charles Dinarello, professor of medicine at the University of Colorado, who discovered and cloned interleukin-1 in the early ’80s,” Cominelli said. “Now I have the opportunity to collaborate again with him in this exciting project that has the potential to develop a novel biological therapy for patients with IBD.”

IBD, which refers to Crohn’s disease and ulcerative colitis, affects more than three million adults in the United States, according to the Centers for Disease Control and Prevention. and 10 Million Worldwide according to the European Federation of Crohn’s & Ulcerative Colitis Associations (EFCCA). This estimate does not include children who may also have IBD, who are being diagnosed younger and with more aggressive cases than ever before.. Most people with IBD are diagnosed in their 20s and 30s, according to the CDC.

These ailments are chronic, relapsing, inflammatory conditions of the gastrointestinal system characterized by severe pain, diarrhea, bleeding and sometimes intestinal complications requiring surgery. Woman with Ulcerative Colitis who require surgery have seen their fertility rates drop by one-third.

To date, there is no cure for these devastating diseases, and available conventional medicine therapies are effective in only about half of IBD patients.

“Therefore, there is a great need for developing new biological therapies, such as anti-IL1 monoclonal antibodies,” Cominelli said.

Some of those interviewed for the Crohn’s And Colitis Summit would disagree as they believe they are cured. Some no longer require a special diet.

BTW – Looking To Order Blood Tests Without The Hassle Of Going Through Your Doctor and Insurance Companies Approval? Now you can, read more here. HSA +FSA Accounts accepted.

Categories
Abdominal Pain Cancer Cramps Crohn's Disease Depression DIAGNOSIS Events Hospital Inflammation Joel's Story LOVE One Great Gut Collection Resources Self Love STORIES-OF-HOPE SYMPTOMS TREATMENT Ulcerative Colitis

Myth: You are one illness away from bankruptcy

Yesterday: “You are one illness away from bankruptcy” 😕

Today: “You are one ambulance ride away from bankruptcy” 😧😲

Only 23% of Americans are able to afford an unexpected medical bill that more than $2,000, yet out-of-pocket medical costs keep rising.

That’s because the #1 reason for bankruptcy in America is medical bills

Not Job Loss

Not Divorce

Not Student Loans, Foreclosure or a Failed Business

MEDICAL BILLS

My last Ambulance🚑 Ride on March 26, 2017, cost me over $2,500 – for a six-mile ride from Sorrento Valley when I was living with Ipek, Craig, and Faith who were at work.

I could barely walk.

A world of pain

Hyper-inflammation destroying my body

3:45pm is when my body said enough was enough

I called 9️⃣1️⃣1️⃣

My body relaxed

I curled up on the floor

🆘 Help was on the way

I remember the embarrassment and shame wondering what the neighbors would think about an ambulance pulling up to the house

My body told my mind to chill. That’s not important. What’s important is that I finally reached out for help.

The doorbell rang

I waited

Determination to save the 🏠front door and windows kicked in

Ipek kept the home so clean I’d hate for her to have to clean up broken glass.

Somehow I made it to the front door

The paramedics questioned why I even called them in the first place

My disheveled unshowered look while wearing Lululemon sweats didn’t explain the full story

There was no obvious bleeding or broken bones

Crohn’s and Colitis are known as INVISIBLE ILLNESSES

An umbrella🌂 term for any medical condition that isn’t easily visible to others

Conditions like heart disease, diabetes, dementia, psychiatric illness, other autoimmune disorders, and even cancer

Exactly why we all should BE KIND, ALWAYS 

 You Never Know What Someone Is Going Through 

Most of those are who filed for bankruptcy due to medical bills had health insurance

That’s because if you’re dealing with a chronic disease you’re likely spending a boatload of money that’s not covered by insurance

According to Medical Billing Advocates of America up to 80% of medical bills contain errors – and the problem is getting worse

With 70,000 diagnosis codes and 71,000 procedure codes to sift through not even a person with an IQ of 180 would get this right 100% of the time.

The system is beyond broken

If you or someone you know is dealing with medical bills, now you can learn from a health care attorney who has negotiated over $500,000 in medical bills down for his clients.

And from patient advocate, David Dubé, who from his own personal journey with his Mom has negotiated over $50,000 in medical bills.

In a simple, proven 12-step process you will learn how to

👍Win Insurance Appeals

👍 Stop getting pushed by using attorney approved response letters and appeal resource

👍Spot & Correct The 80% Of Billing Errors

👍Negotiate Bills Down by leveraging statistics, industry data and time tested techniques

One user of this system said:

“I had no idea I could negotiate medical bills down. I was able to negotiate my medical bill from $2,348 down to $1000, That’s a 43% reduction on my first try!”

All with a 14 Day Full 💯% Money Back Guarantee Policy

The One Great Gut Collection includes a 20% off coupon for the program.

Sign up on the early-bird list to get access.

Since I know bills are time🕐sensitive, comment below if you would like access to start winning insurance appeals today

Love,
Joel

Categories
Abdominal Bloating Abdominal Pain Arthritis Cancer Constipation Crohn's Disease Depression Diarrhea EAT Fatigue Gas-Flatulence Headache Inflammation Mood Changes Nutrition RESEARCH Ulcerative Colitis

Impossible Burger = The Ecoside Burger

The Ecosystem of the Earth and the Ecosystem of your body.

Good Branding + good marketing, and a snazzy website does not necessarily mean good health

Health is Wealth. Without health, what do you have?

A companies claim that their Mission is to “Save Earth” needs substance, not just convincing words and fancy pictures on their website.

 If you think the Impossible Burger is in any way a health food, think again.

🤔And if you think eating this laboratory experiment is better for the environment, again, you’d better investigate this a little more.

😲 If you think Impossible Burger cares about Moms. Think again

🤢 YUCK! When we look at the ingredients, we see mostly genetically engineered soy – AKA soy that is heavily sprayed heavily with Roundup (glyphosate).

😲 Why is this bad? Well, Roundup is a WATER-SOLUBLE chemical. This means when it gets sprayed on crops, some of it works its way into our soil and then our streams and rivers, some of it gets evaporated into the air we breathe, and eventually, it can even come back down in the rain that falls on us. Yep, thanks to governing bodies that don’t have our backs, our entire environment is now contaminated with this junk.

🔘This wouldn’t be such an issue if Roundup consumption didn’t contribute to Cancer, Crohn’s disease, Ulcerative Colitis, Celiac disease, Fatty liver disease, Autism, Alzheimer’s, and a whole host of other chronic illnesses. The Impossible Burger tested POSITIVE for Glyphosate.

The Impossible Burger🤭So when you eat your Impossible Burger thinking you’re being healthy, remember that all you’re doing is slowly increasing your risk for cancer and chronic disease (Not that eating industrial meat would be any better. Always stick to local farms and grass-fed animals)

🤭And when you think you’re supporting the environment, remember that you’re really supporting the slow destruction of our planet because of More Genetically Engineered Crops = More Roundup Sprayed = More Toxic Earth

👩‍👧‍👦 Impossible Burger attacked Moms Across America (MAA) founded by Zen Honeycutt for speaking the truth and publishing the pesticide results of this impossibly unhealthy burger. Rather than acknowledging that glyphosate in their food could be a problem — especially in light of the recent court cases against Bayer (which acquired Monsanto in 2018) totaling billions in judgments due to people who developed cancer as a result of Roundup use — they engaged in a veritable smear campaign against MAA, including insults and name-calling.

As for MAA’s statements that glyphosate-based herbicides have been “proven to be carcinogenic,” Impossible Foods stated this is “a ridiculous claim” and “No regulatory authority in the world considers glyphosate to be carcinogenic to humans at current exposure levels,” tell this to the victims behind the at least 13,400 lawsuits that have been filed claiming exposure to glyphosate-containing Roundup caused health problems, including cancer.

🖍 Pat Brown, the CEO, and Founder of Impossible Foods wrote a Medium dot com article entitled How our commitment to consumers and our planet led us to use GM soy with a lot of numbers and “facts”🤥.

Three comments on that post sum up my opinion:
a) This is either asinine, diabolical, or both. One word: boycott.

b) Industrial legume ag is an act of violence upon the earth.

c) Bullshit

I actually tried the impossible burger highly processed pseudo-food recently, wasn’t too impressed with the flavor, nor how I felt afterward. 🤢 Swipe Left. Next!

🙏 Guy Fasciana for your research which inspired me to dig deeper

🙏 – Regenetarianism – Formerly L.A. Chef’s Column

🙏 Organic Consumers Association

Categories
Crohn's Disease DIAGNOSIS Emotional Events One Great Gut Collection RESEARCH Resources SYMPTOMS TREATMENT Ulcerative Colitis

There’s No Crying In Baseball

Stop being a wuss

Man up

You throw like a girl

Doesn’t she look fat? She looks large and in charge.

I think it’s time you get over it

You would look so pretty if_____

You’re single? You must be so lonely!

Quit whining

What do these insensitive comments have to do with gut health?

Everything

Dr. Detko Emotional Health Crohn's ColitisHarvard Medical School reviewed 13 studies showing that patients who tried psychologically based approaches had greater improvement in their digestive symptoms compared with patients who received only conventional medical treatment.

Words can affect your emotions which then impact your physical body.

I was once asked to reprimand an employee. As I was about to enter her office I was hit with a massive headache.

Another time I was receiving an award at toastmasters and looking back at the pictures you can see my stomach go from flat to massively bloated in just a few picture frames solely because of this thing called “receiving an award”.

No food or drink played a part in the bloating!

Emotional Constipation and Emotional Hangovers are real

In this module, Dr. Eva Detko PhD has created an exclusive personalized PDF specific for gut health. For IBD Crohn’s and Colitis.

Since Dr. Detko created this specifically for the One Great Gut Community, this PDF is not available anywhere else. It explains why addressing diet on its own is not sufficient, how and why the body can not heal when it is stressed, and how your physiological processes can make you sick, or make you THRIVE depending on your response to them.

This PDF is not just about information. It’s about solutions. Dr. Detko offers more than eight solutions that will accelerate your healing.

Thank You Dr. Detko!

Sign Up On the Early Bird List for free: http://bit.ly/get-oggc

Note: This PDF is available free to all those who purchase the One Great Gut Collection. A portion of all proceeds will enable the One Great Gut Foundation to get closer to a cure for IBD Crohn’s Colitis. For every One Great Gut Collection purchased, we’ll donate funds to make that happen. So you can invest in your health and build a healthier world our initiatives.